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Amy Moreno
Amy Moreno
Department of Surgical Oncology, Department of Gastrointestinal Medical Oncology
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Argun Akcakanat
Argun Akcakanat
Department of Surgical Oncology, Department of Gastrointestinal Medical Oncology
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Mark F Munsell
Mark F Munsell
Department of Surgical Oncology, Department of Gastrointestinal Medical Oncology
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Alpana Soni
Alpana Soni
Department of Surgical Oncology, Department of Gastrointestinal Medical Oncology
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James C Yao
James C Yao
Department of Surgical Oncology, Department of Gastrointestinal Medical Oncology
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Funda Meric-Bernstam
Funda Meric-Bernstam
Department of Surgical Oncology, Department of Gastrointestinal Medical Oncology
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phosphatidylinositol-3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) signaling pathway has recently emerged as a potential target for cancer therapy. mTOR signaling is activated in many tumor types. The activated mTOR kinase in a complex with raptor (mTORC1
Alexander Gorshtein
Alexander Gorshtein
Institute of Endocrinology and Metabolism and Felsenstein Medical Research Center, Sackler School of Medicine, Department of Internal Medicine E, Department of Endocrinology, Department of Neurosurgery, Rabin Medical Center, Beilinson Campus, Petach Tikva 49100, Israel
Institute of Endocrinology and Metabolism and Felsenstein Medical Research Center, Sackler School of Medicine, Department of Internal Medicine E, Department of Endocrinology, Department of Neurosurgery, Rabin Medical Center, Beilinson Campus, Petach Tikva 49100, Israel
Institute of Endocrinology and Metabolism and Felsenstein Medical Research Center, Sackler School of Medicine, Department of Internal Medicine E, Department of Endocrinology, Department of Neurosurgery, Rabin Medical Center, Beilinson Campus, Petach Tikva 49100, Israel
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Institute of Endocrinology and Metabolism and Felsenstein Medical Research Center, Sackler School of Medicine, Department of Internal Medicine E, Department of Endocrinology, Department of Neurosurgery, Rabin Medical Center, Beilinson Campus, Petach Tikva 49100, Israel
Institute of Endocrinology and Metabolism and Felsenstein Medical Research Center, Sackler School of Medicine, Department of Internal Medicine E, Department of Endocrinology, Department of Neurosurgery, Rabin Medical Center, Beilinson Campus, Petach Tikva 49100, Israel
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Hadara Rubinfeld
Hadara Rubinfeld
Institute of Endocrinology and Metabolism and Felsenstein Medical Research Center, Sackler School of Medicine, Department of Internal Medicine E, Department of Endocrinology, Department of Neurosurgery, Rabin Medical Center, Beilinson Campus, Petach Tikva 49100, Israel
Institute of Endocrinology and Metabolism and Felsenstein Medical Research Center, Sackler School of Medicine, Department of Internal Medicine E, Department of Endocrinology, Department of Neurosurgery, Rabin Medical Center, Beilinson Campus, Petach Tikva 49100, Israel
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Institute of Endocrinology and Metabolism and Felsenstein Medical Research Center, Sackler School of Medicine, Department of Internal Medicine E, Department of Endocrinology, Department of Neurosurgery, Rabin Medical Center, Beilinson Campus, Petach Tikva 49100, Israel
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Efrat Kendler
Efrat Kendler
Institute of Endocrinology and Metabolism and Felsenstein Medical Research Center, Sackler School of Medicine, Department of Internal Medicine E, Department of Endocrinology, Department of Neurosurgery, Rabin Medical Center, Beilinson Campus, Petach Tikva 49100, Israel
Institute of Endocrinology and Metabolism and Felsenstein Medical Research Center, Sackler School of Medicine, Department of Internal Medicine E, Department of Endocrinology, Department of Neurosurgery, Rabin Medical Center, Beilinson Campus, Petach Tikva 49100, Israel
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Institute of Endocrinology and Metabolism and Felsenstein Medical Research Center, Sackler School of Medicine, Department of Internal Medicine E, Department of Endocrinology, Department of Neurosurgery, Rabin Medical Center, Beilinson Campus, Petach Tikva 49100, Israel
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Marily Theodoropoulou
Marily Theodoropoulou
Institute of Endocrinology and Metabolism and Felsenstein Medical Research Center, Sackler School of Medicine, Department of Internal Medicine E, Department of Endocrinology, Department of Neurosurgery, Rabin Medical Center, Beilinson Campus, Petach Tikva 49100, Israel
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Vesna Cerovac
Vesna Cerovac
Institute of Endocrinology and Metabolism and Felsenstein Medical Research Center, Sackler School of Medicine, Department of Internal Medicine E, Department of Endocrinology, Department of Neurosurgery, Rabin Medical Center, Beilinson Campus, Petach Tikva 49100, Israel
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Günter K Stalla
Günter K Stalla
Institute of Endocrinology and Metabolism and Felsenstein Medical Research Center, Sackler School of Medicine, Department of Internal Medicine E, Department of Endocrinology, Department of Neurosurgery, Rabin Medical Center, Beilinson Campus, Petach Tikva 49100, Israel
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Zvi R Cohen
Zvi R Cohen
Institute of Endocrinology and Metabolism and Felsenstein Medical Research Center, Sackler School of Medicine, Department of Internal Medicine E, Department of Endocrinology, Department of Neurosurgery, Rabin Medical Center, Beilinson Campus, Petach Tikva 49100, Israel
Institute of Endocrinology and Metabolism and Felsenstein Medical Research Center, Sackler School of Medicine, Department of Internal Medicine E, Department of Endocrinology, Department of Neurosurgery, Rabin Medical Center, Beilinson Campus, Petach Tikva 49100, Israel
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Institute of Endocrinology and Metabolism and Felsenstein Medical Research Center, Sackler School of Medicine, Department of Internal Medicine E, Department of Endocrinology, Department of Neurosurgery, Rabin Medical Center, Beilinson Campus, Petach Tikva 49100, Israel
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Moshe Hadani
Moshe Hadani
Institute of Endocrinology and Metabolism and Felsenstein Medical Research Center, Sackler School of Medicine, Department of Internal Medicine E, Department of Endocrinology, Department of Neurosurgery, Rabin Medical Center, Beilinson Campus, Petach Tikva 49100, Israel
Institute of Endocrinology and Metabolism and Felsenstein Medical Research Center, Sackler School of Medicine, Department of Internal Medicine E, Department of Endocrinology, Department of Neurosurgery, Rabin Medical Center, Beilinson Campus, Petach Tikva 49100, Israel
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Institute of Endocrinology and Metabolism and Felsenstein Medical Research Center, Sackler School of Medicine, Department of Internal Medicine E, Department of Endocrinology, Department of Neurosurgery, Rabin Medical Center, Beilinson Campus, Petach Tikva 49100, Israel
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Ilan Shimon
Ilan Shimon
Institute of Endocrinology and Metabolism and Felsenstein Medical Research Center, Sackler School of Medicine, Department of Internal Medicine E, Department of Endocrinology, Department of Neurosurgery, Rabin Medical Center, Beilinson Campus, Petach Tikva 49100, Israel
Institute of Endocrinology and Metabolism and Felsenstein Medical Research Center, Sackler School of Medicine, Department of Internal Medicine E, Department of Endocrinology, Department of Neurosurgery, Rabin Medical Center, Beilinson Campus, Petach Tikva 49100, Israel
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Institute of Endocrinology and Metabolism and Felsenstein Medical Research Center, Sackler School of Medicine, Department of Internal Medicine E, Department of Endocrinology, Department of Neurosurgery, Rabin Medical Center, Beilinson Campus, Petach Tikva 49100, Israel
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Introduction Rapamycin, a lipophilic macrolide produced by the bacterium Streptomyces hygroscopicus , was initially developed as an anti-fungal agent ( Sehgal et al . 1975 ), but was then found to possess immunosuppressive and anti
Yvonne Fierz
Yvonne Fierz
Division of Endocrinology, Diabetes and Bone Diseases, The Samuel Bronfman Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
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Ruslan Novosyadlyy
Ruslan Novosyadlyy
Division of Endocrinology, Diabetes and Bone Diseases, The Samuel Bronfman Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
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Archana Vijayakumar
Archana Vijayakumar
Division of Endocrinology, Diabetes and Bone Diseases, The Samuel Bronfman Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
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Shoshana Yakar
Shoshana Yakar
Division of Endocrinology, Diabetes and Bone Diseases, The Samuel Bronfman Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
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Derek LeRoith
Derek LeRoith
Division of Endocrinology, Diabetes and Bone Diseases, The Samuel Bronfman Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
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proteins (Bad, caspase-9, and GSK3b), cell cycle inhibitors (p21 and p27), products of tumor suppressor genes (FOX proteins, p53), and induction of signaling through nuclear factor κB (NF-κB) or the mammalian target of rapamycin (mTOR) pathway ( Manning
Eric Monsalves
Eric Monsalves
Institute of Medical Science
Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
Institute of Medical Science
Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
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Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
Institute of Medical Science
Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
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Kyle Juraschka
Kyle Juraschka
Institute of Medical Science
Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
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Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
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Toru Tateno
Toru Tateno
Institute of Medical Science
Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
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Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
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Sameer Agnihotri
Sameer Agnihotri
Institute of Medical Science
Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
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Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
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Sylvia L Asa
Sylvia L Asa
Institute of Medical Science
Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
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Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
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Shereen Ezzat
Shereen Ezzat
Institute of Medical Science
Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
Institute of Medical Science
Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
Institute of Medical Science
Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
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Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
Institute of Medical Science
Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
Institute of Medical Science
Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
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Gelareh Zadeh
Gelareh Zadeh
Institute of Medical Science
Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
Institute of Medical Science
Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
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Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
Institute of Medical Science
Department of Medical Biophysics University of Toronto, Toronto, Ontario, Canada
Division of Neurosurgery Toronto Western Hospital, 399 Bathurst Street, 4W-439, Toronto, Ontario, Canada M5T 2S8
Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ontario, Canada
Endocrine Oncology Site Group Princess Margaret Hospital, Toronto, Ontario, Canada
Department of Laboratory Medicine and Pathobiology University of Toronto, Toronto, Ontario, Canada
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mTOR pathway involvement in PA tumorigenesis and as a target for medical therapy. Effects of rapamycin (and rapalog)-induced mTOR inhibition on PA cellular proliferation and viability Rapamycin (sirolimus) is an immunosuppressant and antiproliferative
Luisella Righi
Luisella Righi
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Marco Volante
Marco Volante
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Ida Rapa
Ida Rapa
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Veronica Tavaglione
Veronica Tavaglione
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Frediano Inzani
Frediano Inzani
Division of Pathology, Division of Pathology, National Cancer Institute and University of Milan, Department of Clinical and Biological Sciences, University of Turin at San Luigi Hospital, Regione Gonzole 10, 10043 Orbassano, Torino, Italy
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Giuseppe Pelosi
Giuseppe Pelosi
Division of Pathology, Division of Pathology, National Cancer Institute and University of Milan, Department of Clinical and Biological Sciences, University of Turin at San Luigi Hospital, Regione Gonzole 10, 10043 Orbassano, Torino, Italy
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Mauro Papotti
Mauro Papotti
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growth factor (VEGF) pathway, and inhibitors of the mammalian target of rapamycin (mTOR), which have shown promising activity in recent clinical studies ( Duran et al . 2007 , Kulke 2007 , Yao et al . 2008 , 2010 ). mTOR is a serine threonine kinase
Leticia M Nogueira
Leticia M Nogueira
Institute of Cell and Molecular Biology, Department of Molecular Carcinogenesis, Department of Nutritional Sciences, University of Texas at Austin, Austin, Texas 78712, USA
Institute of Cell and Molecular Biology, Department of Molecular Carcinogenesis, Department of Nutritional Sciences, University of Texas at Austin, Austin, Texas 78712, USA
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Institute of Cell and Molecular Biology, Department of Molecular Carcinogenesis, Department of Nutritional Sciences, University of Texas at Austin, Austin, Texas 78712, USA
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Sarah M Dunlap
Sarah M Dunlap
Institute of Cell and Molecular Biology, Department of Molecular Carcinogenesis, Department of Nutritional Sciences, University of Texas at Austin, Austin, Texas 78712, USA
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Nikki A Ford
Nikki A Ford
Institute of Cell and Molecular Biology, Department of Molecular Carcinogenesis, Department of Nutritional Sciences, University of Texas at Austin, Austin, Texas 78712, USA
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Stephen D Hursting
Stephen D Hursting
Institute of Cell and Molecular Biology, Department of Molecular Carcinogenesis, Department of Nutritional Sciences, University of Texas at Austin, Austin, Texas 78712, USA
Institute of Cell and Molecular Biology, Department of Molecular Carcinogenesis, Department of Nutritional Sciences, University of Texas at Austin, Austin, Texas 78712, USA
Institute of Cell and Molecular Biology, Department of Molecular Carcinogenesis, Department of Nutritional Sciences, University of Texas at Austin, Austin, Texas 78712, USA
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Institute of Cell and Molecular Biology, Department of Molecular Carcinogenesis, Department of Nutritional Sciences, University of Texas at Austin, Austin, Texas 78712, USA
Institute of Cell and Molecular Biology, Department of Molecular Carcinogenesis, Department of Nutritional Sciences, University of Texas at Austin, Austin, Texas 78712, USA
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. 2006 ). Adiponectin levels also increase following bariatric surgery ( Yang et al . 2001 ). The energy balance-related hormones exert at least some of their effects through a common signaling intermediate, the mammalian target of rapamycin (mTOR
D Barb
D Barb
Division of Endocrinology,, Cancer Biology Program,, Diabetes and Metabolism Biology Program and
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A Neuwirth
A Neuwirth
Division of Endocrinology,, Cancer Biology Program,, Diabetes and Metabolism Biology Program and
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C S Mantzoros
C S Mantzoros
Division of Endocrinology,, Cancer Biology Program,, Diabetes and Metabolism Biology Program and
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S P Balk
S P Balk
Division of Endocrinology,, Cancer Biology Program,, Diabetes and Metabolism Biology Program and
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-activated receptor α (PPARα) effects ( Yamauchi et al . 2002 , 2003 , Yoon et al . 2006 ). Activated AMPK inhibits enzymes that regulate protein, fatty acid, and triglyceride synthesis, including mammalian target of rapamycin (mTOR), acetyl-CoA carboxylase (ACC
Yu-Yu Liu
Yu-Yu Liu
The Ohio State Biochemistry Program, Department of Physiology and Cell Biology, Molecular Virology, Internal Medicine
The Ohio State Biochemistry Program, Department of Physiology and Cell Biology, Molecular Virology, Internal Medicine
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The Ohio State Biochemistry Program, Department of Physiology and Cell Biology, Molecular Virology, Internal Medicine
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Xiaoli Zhang
Xiaoli Zhang
The Ohio State Biochemistry Program, Department of Physiology and Cell Biology, Molecular Virology, Internal Medicine
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Matthew D Ringel
Matthew D Ringel
The Ohio State Biochemistry Program, Department of Physiology and Cell Biology, Molecular Virology, Internal Medicine
The Ohio State Biochemistry Program, Department of Physiology and Cell Biology, Molecular Virology, Internal Medicine
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The Ohio State Biochemistry Program, Department of Physiology and Cell Biology, Molecular Virology, Internal Medicine
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Sissy M Jhiang
Sissy M Jhiang
The Ohio State Biochemistry Program, Department of Physiology and Cell Biology, Molecular Virology, Internal Medicine
The Ohio State Biochemistry Program, Department of Physiology and Cell Biology, Molecular Virology, Internal Medicine
The Ohio State Biochemistry Program, Department of Physiology and Cell Biology, Molecular Virology, Internal Medicine
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The Ohio State Biochemistry Program, Department of Physiology and Cell Biology, Molecular Virology, Internal Medicine
The Ohio State Biochemistry Program, Department of Physiology and Cell Biology, Molecular Virology, Internal Medicine
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by Rapamycin increased NIS expression and NIS-mediated RAIU in PCCl3 cells under acute TSH stimulation ( de Souza et al . 2010 ). To date; however, the effects of LY294002, Akti-1/2, or Rapamycin on NIS modulation in thyroid cells under chronic TSH
T M Sadler
T M Sadler
Department of Oncology, Wyeth Research, 401 North Middle Town Road, Pearl River, New York, New York 10965, USA
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M Gavriil
M Gavriil
Department of Oncology, Wyeth Research, 401 North Middle Town Road, Pearl River, New York, New York 10965, USA
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T Annable
T Annable
Department of Oncology, Wyeth Research, 401 North Middle Town Road, Pearl River, New York, New York 10965, USA
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P Frost
P Frost
Department of Oncology, Wyeth Research, 401 North Middle Town Road, Pearl River, New York, New York 10965, USA
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L M Greenberger
L M Greenberger
Department of Oncology, Wyeth Research, 401 North Middle Town Road, Pearl River, New York, New York 10965, USA
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Y Zhang
Y Zhang
Department of Oncology, Wyeth Research, 401 North Middle Town Road, Pearl River, New York, New York 10965, USA
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et al. 2003 ). Recently, the evidence of cross-talk between the mammalian target of rapamycin (mTOR) pathway and ER is emerging. deGraffenried et al. (2004) demonstrated that rapamycin restored Tam resistance in MCF-7 breast cancer cells
Alessia Di Florio
Alessia Di Florio
Department of Public Health and Cell Biology, Laboratory of Neuroembryology, Digestive and Liver Disease Unit, Department of Clinical and Molecular Medicine, ARC‐NET Research Center, Department of Pathology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
Department of Public Health and Cell Biology, Laboratory of Neuroembryology, Digestive and Liver Disease Unit, Department of Clinical and Molecular Medicine, ARC‐NET Research Center, Department of Pathology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
Department of Public Health and Cell Biology, Laboratory of Neuroembryology, Digestive and Liver Disease Unit, Department of Clinical and Molecular Medicine, ARC‐NET Research Center, Department of Pathology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
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Department of Public Health and Cell Biology, Laboratory of Neuroembryology, Digestive and Liver Disease Unit, Department of Clinical and Molecular Medicine, ARC‐NET Research Center, Department of Pathology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
Department of Public Health and Cell Biology, Laboratory of Neuroembryology, Digestive and Liver Disease Unit, Department of Clinical and Molecular Medicine, ARC‐NET Research Center, Department of Pathology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
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Laura Adesso
Laura Adesso
Department of Public Health and Cell Biology, Laboratory of Neuroembryology, Digestive and Liver Disease Unit, Department of Clinical and Molecular Medicine, ARC‐NET Research Center, Department of Pathology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
Department of Public Health and Cell Biology, Laboratory of Neuroembryology, Digestive and Liver Disease Unit, Department of Clinical and Molecular Medicine, ARC‐NET Research Center, Department of Pathology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
Department of Public Health and Cell Biology, Laboratory of Neuroembryology, Digestive and Liver Disease Unit, Department of Clinical and Molecular Medicine, ARC‐NET Research Center, Department of Pathology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
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Department of Public Health and Cell Biology, Laboratory of Neuroembryology, Digestive and Liver Disease Unit, Department of Clinical and Molecular Medicine, ARC‐NET Research Center, Department of Pathology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
Department of Public Health and Cell Biology, Laboratory of Neuroembryology, Digestive and Liver Disease Unit, Department of Clinical and Molecular Medicine, ARC‐NET Research Center, Department of Pathology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
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Simona Pedrotti
Simona Pedrotti
Department of Public Health and Cell Biology, Laboratory of Neuroembryology, Digestive and Liver Disease Unit, Department of Clinical and Molecular Medicine, ARC‐NET Research Center, Department of Pathology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
Department of Public Health and Cell Biology, Laboratory of Neuroembryology, Digestive and Liver Disease Unit, Department of Clinical and Molecular Medicine, ARC‐NET Research Center, Department of Pathology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
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Department of Public Health and Cell Biology, Laboratory of Neuroembryology, Digestive and Liver Disease Unit, Department of Clinical and Molecular Medicine, ARC‐NET Research Center, Department of Pathology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
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Gabriele Capurso
Gabriele Capurso
Department of Public Health and Cell Biology, Laboratory of Neuroembryology, Digestive and Liver Disease Unit, Department of Clinical and Molecular Medicine, ARC‐NET Research Center, Department of Pathology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
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Emanuela Pilozzi
Emanuela Pilozzi
Department of Public Health and Cell Biology, Laboratory of Neuroembryology, Digestive and Liver Disease Unit, Department of Clinical and Molecular Medicine, ARC‐NET Research Center, Department of Pathology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
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Vincenzo Corbo
Vincenzo Corbo
Department of Public Health and Cell Biology, Laboratory of Neuroembryology, Digestive and Liver Disease Unit, Department of Clinical and Molecular Medicine, ARC‐NET Research Center, Department of Pathology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
Department of Public Health and Cell Biology, Laboratory of Neuroembryology, Digestive and Liver Disease Unit, Department of Clinical and Molecular Medicine, ARC‐NET Research Center, Department of Pathology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
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Department of Public Health and Cell Biology, Laboratory of Neuroembryology, Digestive and Liver Disease Unit, Department of Clinical and Molecular Medicine, ARC‐NET Research Center, Department of Pathology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
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Aldo Scarpa
Aldo Scarpa
Department of Public Health and Cell Biology, Laboratory of Neuroembryology, Digestive and Liver Disease Unit, Department of Clinical and Molecular Medicine, ARC‐NET Research Center, Department of Pathology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
Department of Public Health and Cell Biology, Laboratory of Neuroembryology, Digestive and Liver Disease Unit, Department of Clinical and Molecular Medicine, ARC‐NET Research Center, Department of Pathology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
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Department of Public Health and Cell Biology, Laboratory of Neuroembryology, Digestive and Liver Disease Unit, Department of Clinical and Molecular Medicine, ARC‐NET Research Center, Department of Pathology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
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Raffaele Geremia
Raffaele Geremia
Department of Public Health and Cell Biology, Laboratory of Neuroembryology, Digestive and Liver Disease Unit, Department of Clinical and Molecular Medicine, ARC‐NET Research Center, Department of Pathology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
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Gianfranco Delle Fave
Gianfranco Delle Fave
Department of Public Health and Cell Biology, Laboratory of Neuroembryology, Digestive and Liver Disease Unit, Department of Clinical and Molecular Medicine, ARC‐NET Research Center, Department of Pathology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
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Claudio Sette
Claudio Sette
Department of Public Health and Cell Biology, Laboratory of Neuroembryology, Digestive and Liver Disease Unit, Department of Clinical and Molecular Medicine, ARC‐NET Research Center, Department of Pathology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
Department of Public Health and Cell Biology, Laboratory of Neuroembryology, Digestive and Liver Disease Unit, Department of Clinical and Molecular Medicine, ARC‐NET Research Center, Department of Pathology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
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Department of Public Health and Cell Biology, Laboratory of Neuroembryology, Digestive and Liver Disease Unit, Department of Clinical and Molecular Medicine, ARC‐NET Research Center, Department of Pathology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy
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instance, it induces mRNA translation through activation of the mammalian target of rapamycin (mTOR) serine/threonine kinase ( Gorrini et al . 2005 ). However, whether adhesion-induced activation of protein synthesis relies on SFKs and if it promotes
