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D Campana Dipartimento Clinico di Scienze Radiologiche ed Istopatologiche, Dipartimento di Medicina Interna e Gastroenterologia and

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F Nori Dipartimento Clinico di Scienze Radiologiche ed Istopatologiche, Dipartimento di Medicina Interna e Gastroenterologia and

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R Pezzilli Dipartimento Clinico di Scienze Radiologiche ed Istopatologiche, Dipartimento di Medicina Interna e Gastroenterologia and

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L Piscitelli Dipartimento Clinico di Scienze Radiologiche ed Istopatologiche, Dipartimento di Medicina Interna e Gastroenterologia and

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D Santini Dipartimento Clinico di Scienze Radiologiche ed Istopatologiche, Dipartimento di Medicina Interna e Gastroenterologia and

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E Brocchi Dipartimento Clinico di Scienze Radiologiche ed Istopatologiche, Dipartimento di Medicina Interna e Gastroenterologia and

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R Corinaldesi Dipartimento Clinico di Scienze Radiologiche ed Istopatologiche, Dipartimento di Medicina Interna e Gastroenterologia and

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P Tomassetti Dipartimento Clinico di Scienze Radiologiche ed Istopatologiche, Dipartimento di Medicina Interna e Gastroenterologia and

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somatostatin analog treatment in type I gastric endocrine tumors. Patients and methods From January 2000 to December 2006, all patients admitted to our unit with gastric endocrine tumors underwent the following study protocol. A baseline visit was made in which

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-07-0251
Volume/Issue:
Volume 15: Issue 1
Free access
Sara Pusceddu Department of Medical Oncology, ENETS Center of Excellence, Fondazione IRCCS Istituto Tumori Milano, Milan, Italy

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Antonio Facciorusso Gastroenterology Unit, Department of Surgical and Medical Sciences, University of Foggia, Foggia, Italy

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Luca Giacomelli Polistudium srl, Milan, Italy

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Natalie Prinzi Department of Medical Oncology, ENETS Center of Excellence, Fondazione IRCCS Istituto Tumori Milano, Milan, Italy

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Francesca Corti Department of Medical Oncology, ENETS Center of Excellence, Fondazione IRCCS Istituto Tumori Milano, Milan, Italy

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Monica Niger Department of Medical Oncology, ENETS Center of Excellence, Fondazione IRCCS Istituto Tumori Milano, Milan, Italy

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Massimo Milione Diagnostic Pathology and Laboratory Medicine Department, Fondazione IRCCS Istituto Nazionale dei Tumori, ENETS Center of Excellence, Milan, Italy

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Jorgelina Coppa Gastro-intestinal Surgery and Liver Transplantation Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, ENETS Center of Excellence, Milan, Italy

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Tommaso Cascella Radiology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, ENETS Center of Excellence, Milan, Italy

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Iolanda Pulice Clinical Trial Center, Fondazione IRCCS Istituto Nazionale Tumori, 20133 Milano, Italy

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Lavinia Biamonte Clinical Trial Center, Fondazione IRCCS Istituto Nazionale Tumori, 20133 Milano, Italy

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Simonetta Papa Polistudium srl, Milan, Italy

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Maria Di Bartolomeo Department of Medical Oncology, ENETS Center of Excellence, Fondazione IRCCS Istituto Tumori Milano, Milan, Italy

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Aashni Shah Polistudium srl, Milan, Italy

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Rodolfo Sacco Gastroenterology Unit, Department of Surgical and Medical Sciences, University of Foggia, Foggia, Italy

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Filippo de Braud Department of Medical Oncology, ENETS Center of Excellence, Fondazione IRCCS Istituto Tumori Milano, Milan, Italy
Oncology and Hemato-Oncology Department, Università degli Studi di Milano, Milan, Italy

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). Pharmacological treatment of GEP NETs comprises somatostatin analogs (SSAs; octreotide (OCT) long-acting release and lanreotide (LAN) autogel), chemotherapy, peptide receptor radiotherapy and targeted therapy with everolimus or sunitinib ( Oronsky et al. 2017

Article Type:
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DOI:
https://doi.org/10.1530/ERC-20-0492
Volume/Issue:
Volume 28: Issue 7
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Iulia Potorac CHU de Liège-University of Liège, Liège, Belgium

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Patrick Petrossians CHU de Liège-University of Liège, Liège, Belgium

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Adrian F Daly CHU de Liège-University of Liège, Liège, Belgium

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Orsalia Alexopoulou Université Catholique de Louvain, Brussels, Belgium

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Sophie Borot CHU Jean Minjoz, Besancon, France

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Mona Sahnoun-Fathallah CHU Marseille, Marseille, France

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Frederic Castinetti CHU Marseille, Marseille, France

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France Devuyst Université Libre de Bruxelles, Bruxelles, Belgium

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Marie-Lise Jaffrain-Rea Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila and Neuroendocrinology, Neuromed IRCCS, Pozzilli, Italy

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Claire Briet CHU Angers, Angers, France

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Florina Luca CHU Strasbourg, Strasbourg, France

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Marion Lapoirie CHU Lyon, Lyon, France

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Flavius Zoicas Universitätsklinikum Erlangen, Erlangen, Germany

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Isabelle Simoneau CHU Bocage, Dijon, France

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Alpha M Diallo CHU Reims, Reims, France

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Ammar Muhammad Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands

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Fahrettin Kelestimur Faculty of Medicine, Erciyes University, Kayseri, Turkey

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Elena Nazzari University of Genova, Genova, Italy

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Rogelio Garcia Centeno Hospital Universitario Gregorio Marañon, Madrid, Spain

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Susan M Webb Hospital Sant Pau, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER, Unidad 747), IIB-Sant Pau, ISCIII and Universitat Autònoma de Barcelona (UAB), Barcelona, Spain

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Marie-Laure Nunes CHU Bordeaux, Bordeaux, France

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Vaclav Hana Charles University, Prague, Czech Republic

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Véronique Pascal-Vigneron CHU Nancy, Nancy, France

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Irena Ilovayskaya Moscow Regional Research and Clinical Institute, Russia

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Farida Nasybullina Kazan State Medical Academy, Kazan, Russia

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Samia Achir Centre Pierre et Marie Curie, Algiers, Algeria

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Diego Ferone University of Genova, Genova, Italy

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Sebastian J C M M Neggers Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands

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Brigitte Delemer CHU Reims, Reims, France

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Jean-Michel Petit CHU Bocage, Dijon, France

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Christof Schöfl Center of Endocrinology & Metabolism, Bamberg, Germany

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Gerald Raverot CHU Lyon, Lyon, France

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Bernard Goichot CHU Strasbourg, Strasbourg, France

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Patrice Rodien CHU Angers, Angers, France

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Bernard Corvilain Université Libre de Bruxelles, Bruxelles, Belgium

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Thierry Brue CHU Marseille, Marseille, France

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Franck Schillo CHU Jean Minjoz, Besancon, France

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Luaba Tshibanda CHU de Liège-University of Liège, Liège, Belgium

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Dominique Maiter Université Catholique de Louvain, Brussels, Belgium

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Jean-François Bonneville CHU de Liège-University of Liège, Liège, Belgium

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Albert Beckers CHU de Liège-University of Liège, Liège, Belgium

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: clinical profile and therapeutic responses . Endocrine-Related Cancer 22 353 – 367 . ( doi:10.1530/ERC-15-0038 ) Bevan JS 2005 Clinical review: the antitumoral effects of somatostatin analog therapy in acromegaly . Journal of Clinical

Article Type:
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DOI:
https://doi.org/10.1530/ERC-16-0356
Volume/Issue:
Volume 23: Issue 11
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Giovanni Vitale Department of Clinical Sciences and Community Health (DISCCO), University of Milan, Milan, Italy
Laboratory of Geriatric and Oncologic Neuroendocrinology Research, Istituto Auxologico Italiano IRCCS, Milan, Italy

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Alessandra Dicitore Laboratory of Geriatric and Oncologic Neuroendocrinology Research, Istituto Auxologico Italiano IRCCS, Milan, Italy

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Concetta Sciammarella Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy

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Sergio Di Molfetta Department of Emergency and Organ Transplantation, Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, University of Bari Aldo Moro, Bari, Italy

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Manila Rubino Unit of Gastrointestinal Medical Oncology and Neuroendocrine Tumors, European Institute of Oncology, IEO, Milan, Italy

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Antongiulio Faggiano Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy

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Annamaria Colao Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy

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represented by surgery followed by medical management, such as somatostatin analogs (SSAs), mTOR inhibitors, tyrosine kinase inhibitors, chemotherapy and peptide receptor radionuclide therapy. However, new treatment options to further improve survival outcomes

Article Type:
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https://doi.org/10.1530/ERC-18-0010
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Volume 25: Issue 6
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Dik J Kwekkeboom Departments of, Nuclear Medicine, Surgery, Internal Medicine

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Boen L Kam Departments of, Nuclear Medicine, Surgery, Internal Medicine

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Martijn van Essen Departments of, Nuclear Medicine, Surgery, Internal Medicine

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Jaap J M Teunissen Departments of, Nuclear Medicine, Surgery, Internal Medicine

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Casper H J van Eijck Departments of, Nuclear Medicine, Surgery, Internal Medicine

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Roelf Valkema Departments of, Nuclear Medicine, Surgery, Internal Medicine

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Marion de Jong Departments of, Nuclear Medicine, Surgery, Internal Medicine

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Wouter W de Herder Departments of, Nuclear Medicine, Surgery, Internal Medicine

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Eric P Krenning Departments of, Nuclear Medicine, Surgery, Internal Medicine

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Introduction Peptide receptor scintigraphy in man started with the in vivo demonstration of somatostatin receptor-positive tumors in patients using a radioiodinated somatostatin analog ( Krenning et al . 1989 ). Later, other radiolabeled

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DOI:
https://doi.org/10.1677/ERC-09-0078
Volume/Issue:
Volume 17: Issue 1
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Shoucheng Ning Departments of, Radiation Oncology, Neurosurgery, Medicine, IPSEN

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Susan J Knox Departments of, Radiation Oncology, Neurosurgery, Medicine, IPSEN

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Griffith R Harsh Departments of, Radiation Oncology, Neurosurgery, Medicine, IPSEN

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Michael D Culler Departments of, Radiation Oncology, Neurosurgery, Medicine, IPSEN

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Laurence Katznelson Departments of, Radiation Oncology, Neurosurgery, Medicine, IPSEN
Departments of, Radiation Oncology, Neurosurgery, Medicine, IPSEN

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Introduction Somatostatin is a peptide hormone that exerts its biologic activity, including inhibition of hormone secretion, by interacting with a family of G protein receptors. Administration of somatostatin analogs, such as lanreotide and

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https://doi.org/10.1677/ERC-09-0003
Volume/Issue:
Volume 16: Issue 3
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E Ferrante
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C Pellegrini
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S Bondioni
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E Peverelli
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M Locatelli
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P Gelmini
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P Luciani
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A Peri
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G Mantovani
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S Bosari
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P Beck-Peccoz
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A Spada
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A Lania
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, largely depending on the SST subtype and the cell system considered ( Hofland et al. 1999 , Benali et al. 2000 ). Due to the physiological actions of somatostatin, long acting analogs that bind with high affinity SST2 and, to a less extent, SST5, such

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https://doi.org/10.1677/erc.1.01191
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Volume 13: Issue 3
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Mintallah Haider Moffitt Cancer Center, Department of GI Oncology, Tampa, Florida, USA

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Satya Das Department of GI Oncology, Vanderbilt University, Nashville, Tennessee, USA

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Taymeyah Al-Toubah Moffitt Cancer Center, Department of GI Oncology, Tampa, Florida, USA

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Eleonora Pelle Department of Oncology, University of Bari, Bari, Puglia, Italy

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Ghassan El-Haddad Moffitt Cancer Center, Department of Diagnostic Imaging and Interventional Radiology, Tampa, Florida, USA

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Jonathan Strosberg Moffitt Cancer Center, Department of GI Oncology, Tampa, Florida, USA

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, Remes et al. 2019 ). An emerging class of therapeutics for patients with WD NETs consists of radiolabeled somatostatin analogs (SSA), which fall under the broader therapeutic class of peptide receptor radionuclide therapy (PRRT). PRRT enables the

Article Type:
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DOI:
https://doi.org/10.1530/ERC-20-0360
Volume/Issue:
Volume 28: Issue 3
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Alexandru Saveanu Laboratory of Biochemistry and Molecular Biology, Center of Neurophysiology and Neurobiology of Marseille (CRN2M), Department of Endocrinology, Anatomical Pathology Department, Nuclear Medecine, Endocrine Surgery, Department of Endocrine Surgery, Centre Hospitalo-Universitaire Conception, 147 Boulevard Baille, 13385 Marseille, France
Laboratory of Biochemistry and Molecular Biology, Center of Neurophysiology and Neurobiology of Marseille (CRN2M), Department of Endocrinology, Anatomical Pathology Department, Nuclear Medecine, Endocrine Surgery, Department of Endocrine Surgery, Centre Hospitalo-Universitaire Conception, 147 Boulevard Baille, 13385 Marseille, France

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Mihaela Muresan Laboratory of Biochemistry and Molecular Biology, Center of Neurophysiology and Neurobiology of Marseille (CRN2M), Department of Endocrinology, Anatomical Pathology Department, Nuclear Medecine, Endocrine Surgery, Department of Endocrine Surgery, Centre Hospitalo-Universitaire Conception, 147 Boulevard Baille, 13385 Marseille, France
Laboratory of Biochemistry and Molecular Biology, Center of Neurophysiology and Neurobiology of Marseille (CRN2M), Department of Endocrinology, Anatomical Pathology Department, Nuclear Medecine, Endocrine Surgery, Department of Endocrine Surgery, Centre Hospitalo-Universitaire Conception, 147 Boulevard Baille, 13385 Marseille, France

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Catherine De Micco Laboratory of Biochemistry and Molecular Biology, Center of Neurophysiology and Neurobiology of Marseille (CRN2M), Department of Endocrinology, Anatomical Pathology Department, Nuclear Medecine, Endocrine Surgery, Department of Endocrine Surgery, Centre Hospitalo-Universitaire Conception, 147 Boulevard Baille, 13385 Marseille, France

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David Taieb Laboratory of Biochemistry and Molecular Biology, Center of Neurophysiology and Neurobiology of Marseille (CRN2M), Department of Endocrinology, Anatomical Pathology Department, Nuclear Medecine, Endocrine Surgery, Department of Endocrine Surgery, Centre Hospitalo-Universitaire Conception, 147 Boulevard Baille, 13385 Marseille, France

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Anne-Laure Germanetti Laboratory of Biochemistry and Molecular Biology, Center of Neurophysiology and Neurobiology of Marseille (CRN2M), Department of Endocrinology, Anatomical Pathology Department, Nuclear Medecine, Endocrine Surgery, Department of Endocrine Surgery, Centre Hospitalo-Universitaire Conception, 147 Boulevard Baille, 13385 Marseille, France

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Frederic Sebag Laboratory of Biochemistry and Molecular Biology, Center of Neurophysiology and Neurobiology of Marseille (CRN2M), Department of Endocrinology, Anatomical Pathology Department, Nuclear Medecine, Endocrine Surgery, Department of Endocrine Surgery, Centre Hospitalo-Universitaire Conception, 147 Boulevard Baille, 13385 Marseille, France

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Jean-François Henry Laboratory of Biochemistry and Molecular Biology, Center of Neurophysiology and Neurobiology of Marseille (CRN2M), Department of Endocrinology, Anatomical Pathology Department, Nuclear Medecine, Endocrine Surgery, Department of Endocrine Surgery, Centre Hospitalo-Universitaire Conception, 147 Boulevard Baille, 13385 Marseille, France

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Laurent Brunaud Laboratory of Biochemistry and Molecular Biology, Center of Neurophysiology and Neurobiology of Marseille (CRN2M), Department of Endocrinology, Anatomical Pathology Department, Nuclear Medecine, Endocrine Surgery, Department of Endocrine Surgery, Centre Hospitalo-Universitaire Conception, 147 Boulevard Baille, 13385 Marseille, France

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Alain Enjalbert Laboratory of Biochemistry and Molecular Biology, Center of Neurophysiology and Neurobiology of Marseille (CRN2M), Department of Endocrinology, Anatomical Pathology Department, Nuclear Medecine, Endocrine Surgery, Department of Endocrine Surgery, Centre Hospitalo-Universitaire Conception, 147 Boulevard Baille, 13385 Marseille, France
Laboratory of Biochemistry and Molecular Biology, Center of Neurophysiology and Neurobiology of Marseille (CRN2M), Department of Endocrinology, Anatomical Pathology Department, Nuclear Medecine, Endocrine Surgery, Department of Endocrine Surgery, Centre Hospitalo-Universitaire Conception, 147 Boulevard Baille, 13385 Marseille, France

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Georges Weryha Laboratory of Biochemistry and Molecular Biology, Center of Neurophysiology and Neurobiology of Marseille (CRN2M), Department of Endocrinology, Anatomical Pathology Department, Nuclear Medecine, Endocrine Surgery, Department of Endocrine Surgery, Centre Hospitalo-Universitaire Conception, 147 Boulevard Baille, 13385 Marseille, France

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Anne Barlier Laboratory of Biochemistry and Molecular Biology, Center of Neurophysiology and Neurobiology of Marseille (CRN2M), Department of Endocrinology, Anatomical Pathology Department, Nuclear Medecine, Endocrine Surgery, Department of Endocrine Surgery, Centre Hospitalo-Universitaire Conception, 147 Boulevard Baille, 13385 Marseille, France
Laboratory of Biochemistry and Molecular Biology, Center of Neurophysiology and Neurobiology of Marseille (CRN2M), Department of Endocrinology, Anatomical Pathology Department, Nuclear Medecine, Endocrine Surgery, Department of Endocrine Surgery, Centre Hospitalo-Universitaire Conception, 147 Boulevard Baille, 13385 Marseille, France

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et al . 2009 ). The various effects of somatostatin and its analogs are mediated through five-membrane G protein-coupled receptors: somatostatin receptor subtypes 1–5 (sst 1–5 ). The presence of sst in PCC/PGL has been demonstrated by ligand binding

Article Type:
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DOI:
https://doi.org/10.1530/ERC-10-0175
Volume/Issue:
Volume 18: Issue 2
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Jennifer A Chan
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David P Ryan Department of Medical Oncology, Department of Hematology/Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, USA

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Andrew X Zhu Department of Medical Oncology, Department of Hematology/Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, USA

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Thomas A Abrams
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Brian M Wolpin
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Paige Malinowski
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Eileen M Regan
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Charles S Fuchs
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Matthew H Kulke
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Introduction Somatostatin analogs have been widely used in patients with advanced neuroendocrine tumors for the treatment of carcinoid syndrome and related symptoms of hormone hypersecretion ( Kvols et al . 1986 , di Bartolomeo et al . 1996

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DOI:
https://doi.org/10.1530/ERC-11-0382
Volume/Issue:
Volume 19: Issue 5
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