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Alfred King-yin Lam School of Medicine, Griffith University, Gold Coast, Australia

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Introduction Squamous cell carcinoma is a rare tumour of the thyroid gland. In the second edition of the World Health Organization (WHO) Histological Typing of Thyroid Tumours published in 1988, squamous cell carcinoma of the thyroid gland was

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Yi-Lin Chang Department of Life Science Institute of Biotechnology, National Dong Hwa University, Hualien 97401, Taiwan

Department of Pathology

Department of Dentistry Mennonite Hospital, Hualien 970, Taiwan, Republic of China

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Yu-Kan Hsu Department of Life Science Institute of Biotechnology, National Dong Hwa University, Hualien 97401, Taiwan

Department of Pathology

Department of Dentistry Mennonite Hospital, Hualien 970, Taiwan, Republic of China

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Tsung-Fan Wu Department of Life Science Institute of Biotechnology, National Dong Hwa University, Hualien 97401, Taiwan

Department of Pathology

Department of Dentistry Mennonite Hospital, Hualien 970, Taiwan, Republic of China

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Chieh-Ming Huang Department of Life Science Institute of Biotechnology, National Dong Hwa University, Hualien 97401, Taiwan

Department of Pathology

Department of Dentistry Mennonite Hospital, Hualien 970, Taiwan, Republic of China
Department of Life Science Institute of Biotechnology, National Dong Hwa University, Hualien 97401, Taiwan

Department of Pathology

Department of Dentistry Mennonite Hospital, Hualien 970, Taiwan, Republic of China

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Li-Yin Liou Department of Life Science Institute of Biotechnology, National Dong Hwa University, Hualien 97401, Taiwan

Department of Pathology

Department of Dentistry Mennonite Hospital, Hualien 970, Taiwan, Republic of China

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Ya-Wen Chiu Department of Life Science Institute of Biotechnology, National Dong Hwa University, Hualien 97401, Taiwan

Department of Pathology

Department of Dentistry Mennonite Hospital, Hualien 970, Taiwan, Republic of China

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Yu-Hsuan Hsiao Department of Life Science Institute of Biotechnology, National Dong Hwa University, Hualien 97401, Taiwan

Department of Pathology

Department of Dentistry Mennonite Hospital, Hualien 970, Taiwan, Republic of China

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Fuh-Jinn Luo Department of Life Science Institute of Biotechnology, National Dong Hwa University, Hualien 97401, Taiwan

Department of Pathology

Department of Dentistry Mennonite Hospital, Hualien 970, Taiwan, Republic of China

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Ta-Chun Yuan Department of Life Science Institute of Biotechnology, National Dong Hwa University, Hualien 97401, Taiwan

Department of Pathology

Department of Dentistry Mennonite Hospital, Hualien 970, Taiwan, Republic of China

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endometrial cancers; however, the role of ERs in oral squamous cell carcinoma (OSCC) is less understood. Previous studies have shown that the expression of ERα and ERβ in OSCC tumors and cell lines, and treatment with tamoxifen significantly, inhibits cell

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C Christofer Juhlin Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden
Department of Pathology and Cancer Diagnostics, Karolinska University Hospital, Stockholm, Sweden

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Ozgur Mete Department of Pathology, University Health Network, Toronto, ON, Canada
Endocrine Oncology Site, Princess Margaret Cancer Centre, Toronto, ON, Canada
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada

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Zubair W Baloch Department of Pathology & Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

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follicular growth (insert). Tumor necrosis is noted (black arrow). Anaplastic thyroid carcinoma In the fourth edition of the WHO classification, squamous cell carcinoma (SCC) of the thyroid gland was listed as a separate entity from anaplastic

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Balaji Ramachandran Department of Molecular Oncology, Cancer Institute (W.I.A.), Adyar, Chennai, India

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–control studies conducted in four different continents and indicated that multiple pregnancies could increase the risk of squamous cell carcinoma of the cervix in HPV-infected women ( Muñoz et al. 2002 ). Gierisch and coworkers ( Gierisch et al . 2013 ) made a

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Achim Fleischmann Division of Cell Biology and Experimental Cancer Research, Institute of Pathology, University of Bern, Murtenstrasse 31, PO Box 62, CH-3010 Bern, Switzerland

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Beatrice Waser Division of Cell Biology and Experimental Cancer Research, Institute of Pathology, University of Bern, Murtenstrasse 31, PO Box 62, CH-3010 Bern, Switzerland

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Jean Claude Reubi Division of Cell Biology and Experimental Cancer Research, Institute of Pathology, University of Bern, Murtenstrasse 31, PO Box 62, CH-3010 Bern, Switzerland

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tumors were analyzed: 134 breast cancers (113 invasive ductal carcinomas, 21 invasive lobular carcinomas); 57 lung cancers (29 squamous carcinomas, 17 adenocarcinomas, two large cell carcinomas, nine small cell carcinomas (SCLC)); 50 prostate cancers

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Nidal Muhanna Guided Therapeutic (GTx) Program, TECHNA Institute, Princess Margaret Cancer Center and University Health Network, Toronto, Ontario, Canada
Department of Otolaryngology-Head and Neck Surgery-Surgical Oncology, Princess Margaret Cancer Centre/University Health Network, University of Toronto, Toronto, Ontario, Canada
Department of Otolaryngology-Head and Neck Surgery, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel

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Harley H L Chan Guided Therapeutic (GTx) Program, TECHNA Institute, Princess Margaret Cancer Center and University Health Network, Toronto, Ontario, Canada
Department of Otolaryngology-Head and Neck Surgery-Surgical Oncology, Princess Margaret Cancer Centre/University Health Network, University of Toronto, Toronto, Ontario, Canada

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Jason L Townson Guided Therapeutic (GTx) Program, TECHNA Institute, Princess Margaret Cancer Center and University Health Network, Toronto, Ontario, Canada
Department of Otolaryngology-Head and Neck Surgery-Surgical Oncology, Princess Margaret Cancer Centre/University Health Network, University of Toronto, Toronto, Ontario, Canada

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Cheng S Jin Guided Therapeutic (GTx) Program, TECHNA Institute, Princess Margaret Cancer Center and University Health Network, Toronto, Ontario, Canada
Department of Otolaryngology-Head and Neck Surgery-Surgical Oncology, Princess Margaret Cancer Centre/University Health Network, University of Toronto, Toronto, Ontario, Canada

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Lili Ding Guided Therapeutic (GTx) Program, TECHNA Institute, Princess Margaret Cancer Center and University Health Network, Toronto, Ontario, Canada

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Michael S Valic Guided Therapeutic (GTx) Program, TECHNA Institute, Princess Margaret Cancer Center and University Health Network, Toronto, Ontario, Canada

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Catriona M Douglas Guided Therapeutic (GTx) Program, TECHNA Institute, Princess Margaret Cancer Center and University Health Network, Toronto, Ontario, Canada
Department of Otolaryngology-Head and Neck Surgery-Surgical Oncology, Princess Margaret Cancer Centre/University Health Network, University of Toronto, Toronto, Ontario, Canada

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Christina M MacLaughlin Guided Therapeutic (GTx) Program, TECHNA Institute, Princess Margaret Cancer Center and University Health Network, Toronto, Ontario, Canada

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Juan Chen Guided Therapeutic (GTx) Program, TECHNA Institute, Princess Margaret Cancer Center and University Health Network, Toronto, Ontario, Canada

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Gang Zheng Guided Therapeutic (GTx) Program, TECHNA Institute, Princess Margaret Cancer Center and University Health Network, Toronto, Ontario, Canada
Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada

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Jonathan C Irish Guided Therapeutic (GTx) Program, TECHNA Institute, Princess Margaret Cancer Center and University Health Network, Toronto, Ontario, Canada
Department of Otolaryngology-Head and Neck Surgery-Surgical Oncology, Princess Margaret Cancer Centre/University Health Network, University of Toronto, Toronto, Ontario, Canada

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-associated rabbit squamous cell carcinoma, has been used for decades as a pre-clinical model of multiple types of cancer, including liver, kidney, brain, pancreas and head and neck cancer ( Rous et al. 1952 , Lin et al. 2009 , Parvinian et al. 2014 ). While

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Kellen Cristine Tjioe Psychoneuroimmunology Laboratory, Psychosomatic Research Center, Oral Oncology Center, School of Dentistry, São Paulo State University (Unesp), Araçatuba, São Paulo, Brazil
Laboratory of Immunopharmacology, Department of Basic Sciences, School of Dentistry, São Paulo State University (Unesp), Araçatuba, São Paulo, Brazil

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Diovana Melo Cardoso Psychoneuroimmunology Laboratory, Psychosomatic Research Center, Oral Oncology Center, School of Dentistry, São Paulo State University (Unesp), Araçatuba, São Paulo, Brazil

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Sandra Helena Penha Oliveira Psychoneuroimmunology Laboratory, Psychosomatic Research Center, Oral Oncology Center, School of Dentistry, São Paulo State University (Unesp), Araçatuba, São Paulo, Brazil
Laboratory of Immunopharmacology, Department of Basic Sciences, School of Dentistry, São Paulo State University (Unesp), Araçatuba, São Paulo, Brazil

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Daniel Galera Bernabé Psychoneuroimmunology Laboratory, Psychosomatic Research Center, Oral Oncology Center, School of Dentistry, São Paulo State University (Unesp), Araçatuba, São Paulo, Brazil

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squamous cell carcinoma (HNSCC) cell lines to cisplatin, one of the most used chemotherapeutics in the management of oral cancer. Additionally, the mechanisms of chemoresistance triggered by ADRB activation were investigated and a cell signaling pathway was

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J S Davies Department of Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, UK

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D A Rees Department of Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, UK

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L M Evans Department of Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, UK

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M F Scanlon Department of Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, UK

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Abstract

We report a case of apoplexy of an undiagnosed pituitary adenoma in a patient treated with intravenous combination chemotherapy for squamous cell carcinoma of the penis. Apoplexy occurred while he was receiving a second cycle of vinblastine, cisplatin and methotrexate and he presented with classic neuro-ophthalmological signs. He made a full recovery following conservative management with steroids alone.

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Soomin Ahn Department of Pathology, Ewha Womans University School of Medicine, Seoul, Korea

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Tae Hyuk Kim Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Sun Wook Kim Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Chang Seok Ki Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Hye Won Jang Department of Medical Education, Sungkyunkwan University School of Medicine, Seoul, Korea

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Jee Soo Kim Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Jung Han Kim Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Jun-Ho Choe Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Jung Hee Shin Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Soo Yeon Hahn Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Young Lyun Oh Department of Pathology and Translational genomics, Sungkyunkwan University School of Medicine, Seoul, Korea

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Jae Hoon Chung Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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87.5% of thyroid carcinoma, which varies according to studies and is higher than other cancer types ( Cunha et al. 2013 , Angell et al. 2014 , Patel & Kurzrock 2015 , Wu et al. 2015 , Bastman et al. 2016 Chowdhury et al. 2016

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Alfred King-yin Lam Cancer Molecular Pathology, School of Medicine and Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia

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Nassim Saremi Cancer Molecular Pathology, School of Medicine and Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia

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carcinoma has prominent squamous areas, which could resemble morules. However, diffuse sclerosing variant had numerous psammoma bodies ( Lam & Lo 2006 , Pillai et al . 2015 ). In contrast, in CMV-PTC, psammoma bodies are rare or absent. In the literature

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