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Clay E S Comstock Department of Cancer Biology, Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, 233 S 10th Street, BLSB 1008, Philadelphia, Pennsylvania 19107, USA
Department of Cancer Biology, Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, 233 S 10th Street, BLSB 1008, Philadelphia, Pennsylvania 19107, USA

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Karen E Knudsen Department of Cancer Biology, Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, 233 S 10th Street, BLSB 1008, Philadelphia, Pennsylvania 19107, USA
Department of Cancer Biology, Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, 233 S 10th Street, BLSB 1008, Philadelphia, Pennsylvania 19107, USA
Department of Cancer Biology, Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, 233 S 10th Street, BLSB 1008, Philadelphia, Pennsylvania 19107, USA
Department of Cancer Biology, Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, 233 S 10th Street, BLSB 1008, Philadelphia, Pennsylvania 19107, USA

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et al . (2013) , published in the April 2013 issue of Endocrine-Related Cancer , IGF2 was unexpectedly identified as a key factor able to induce de novo steroidogenesis in prostate cancer cells. Notably, high levels of IGF2 have been implicated

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Amy A Lubik Institute of Health and Biomedical Innovation, Vancouver Prostate Centre, Departments of Medicine and Oncology, Australian Prostate Cancer Research Centre – Queensland, Princess Alexandra Hospital, Queensland University of Technology, Level 1, Building 1, 199 Ipswich Road, Brisbane, Queensland 4102, Australia
Institute of Health and Biomedical Innovation, Vancouver Prostate Centre, Departments of Medicine and Oncology, Australian Prostate Cancer Research Centre – Queensland, Princess Alexandra Hospital, Queensland University of Technology, Level 1, Building 1, 199 Ipswich Road, Brisbane, Queensland 4102, Australia

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Jennifer H Gunter Institute of Health and Biomedical Innovation, Vancouver Prostate Centre, Departments of Medicine and Oncology, Australian Prostate Cancer Research Centre – Queensland, Princess Alexandra Hospital, Queensland University of Technology, Level 1, Building 1, 199 Ipswich Road, Brisbane, Queensland 4102, Australia

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Brett G Hollier Institute of Health and Biomedical Innovation, Vancouver Prostate Centre, Departments of Medicine and Oncology, Australian Prostate Cancer Research Centre – Queensland, Princess Alexandra Hospital, Queensland University of Technology, Level 1, Building 1, 199 Ipswich Road, Brisbane, Queensland 4102, Australia

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Susan Ettinger Institute of Health and Biomedical Innovation, Vancouver Prostate Centre, Departments of Medicine and Oncology, Australian Prostate Cancer Research Centre – Queensland, Princess Alexandra Hospital, Queensland University of Technology, Level 1, Building 1, 199 Ipswich Road, Brisbane, Queensland 4102, Australia

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Ladan Fazli Institute of Health and Biomedical Innovation, Vancouver Prostate Centre, Departments of Medicine and Oncology, Australian Prostate Cancer Research Centre – Queensland, Princess Alexandra Hospital, Queensland University of Technology, Level 1, Building 1, 199 Ipswich Road, Brisbane, Queensland 4102, Australia

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Nataly Stylianou Institute of Health and Biomedical Innovation, Vancouver Prostate Centre, Departments of Medicine and Oncology, Australian Prostate Cancer Research Centre – Queensland, Princess Alexandra Hospital, Queensland University of Technology, Level 1, Building 1, 199 Ipswich Road, Brisbane, Queensland 4102, Australia

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Stephen C Hendy Institute of Health and Biomedical Innovation, Vancouver Prostate Centre, Departments of Medicine and Oncology, Australian Prostate Cancer Research Centre – Queensland, Princess Alexandra Hospital, Queensland University of Technology, Level 1, Building 1, 199 Ipswich Road, Brisbane, Queensland 4102, Australia

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Hans H Adomat Institute of Health and Biomedical Innovation, Vancouver Prostate Centre, Departments of Medicine and Oncology, Australian Prostate Cancer Research Centre – Queensland, Princess Alexandra Hospital, Queensland University of Technology, Level 1, Building 1, 199 Ipswich Road, Brisbane, Queensland 4102, Australia

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Martin E Gleave Institute of Health and Biomedical Innovation, Vancouver Prostate Centre, Departments of Medicine and Oncology, Australian Prostate Cancer Research Centre – Queensland, Princess Alexandra Hospital, Queensland University of Technology, Level 1, Building 1, 199 Ipswich Road, Brisbane, Queensland 4102, Australia

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Michael Pollak Institute of Health and Biomedical Innovation, Vancouver Prostate Centre, Departments of Medicine and Oncology, Australian Prostate Cancer Research Centre – Queensland, Princess Alexandra Hospital, Queensland University of Technology, Level 1, Building 1, 199 Ipswich Road, Brisbane, Queensland 4102, Australia

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Adrian Herington Institute of Health and Biomedical Innovation, Vancouver Prostate Centre, Departments of Medicine and Oncology, Australian Prostate Cancer Research Centre – Queensland, Princess Alexandra Hospital, Queensland University of Technology, Level 1, Building 1, 199 Ipswich Road, Brisbane, Queensland 4102, Australia

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Colleen C Nelson Institute of Health and Biomedical Innovation, Vancouver Prostate Centre, Departments of Medicine and Oncology, Australian Prostate Cancer Research Centre – Queensland, Princess Alexandra Hospital, Queensland University of Technology, Level 1, Building 1, 199 Ipswich Road, Brisbane, Queensland 4102, Australia
Institute of Health and Biomedical Innovation, Vancouver Prostate Centre, Departments of Medicine and Oncology, Australian Prostate Cancer Research Centre – Queensland, Princess Alexandra Hospital, Queensland University of Technology, Level 1, Building 1, 199 Ipswich Road, Brisbane, Queensland 4102, Australia

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receptors or increase AR sensitivity to low androgen and drive progression ( Stanbrough et al . 2006 , Locke et al . 2008 ). We recently reported that insulin, which rises in response to ADT, can drive expression of steroidogenesis enzymes in PC cells

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David Fu Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology

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Xiangmin Lv Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology

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Guohua Hua Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology

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Chunbo He Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology

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Jixin Dong Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology

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Subodh M Lele Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology

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David Wan-Cheng Li Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology

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Qiongli Zhai Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology

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John S Davis Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology

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Cheng Wang Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology

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regulation of GCT cell proliferation, migration, and steroidogenesis using the KGN human GCT cell line as a cellular model. Our results indicate that the Hippo/YAP signaling pathway plays a critical role in the regulation of GCT progression. Materials and

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Parvin Yenki The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada

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Satyam Bhasin The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada

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Liang Liu The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada

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Noushin Nabavi The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada

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Chi Wing Cheng The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada

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Kevin J Tam The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada

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James W Peacock The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada

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Hans H Adomat The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada

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Tabitha Tombe The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada

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Ladan Fazli The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada

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Larissa Ivanova The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada

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Christopher Dusek The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada

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Shahram Khosravi The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada

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Emma S Tomlinson Guns The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada

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Yuzhuo Wang The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada

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Ralph Buttyan The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada

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Martin E Gleave The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada

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Christopher J Ong The Vancouver Prostate Centre, Vancouver General Hospital, Vancouver, BC, Canada
Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada

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poorly understood. This study is a step toward unraveling the signaling programs that affect steroidogenesis in PCa cells. Several lines of evidence suggest that activation of various receptor tyrosine kinase (RTK) pathways can stimulate steroidogenesis

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Masaki Shiota Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

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Satoshi Endo United Graduate School of Medical Information Sciences, Gifu University, Gifu, Japan
Center for One Medicine Innovative Translational Research (COMIT), Gifu University, Gifu, Japan

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Shigehiro Tsukahara Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

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Tokiyoshi Tanegashima Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

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Satoshi Kobayashi Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

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Takashi Matsumoto Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

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Masatoshi Eto Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

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steroidogenic enzymes, including HSD3B1 , in prostate cancer cells, supporting the contribution of steroidogenesis upregulation to tumor growth at the bone-metastatic site ( Hagberg Thulin et al. 2016 , Huang et al. 2021 ). Figure 2 Schematic

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Régia Caroline Peixoto Lira Department of Pediatrics, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, São Paulo, Brazil

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Paola Fernanda Fedatto Department of Pediatrics, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, São Paulo, Brazil

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David Santos Marco Antonio Department of Research and Development, Fleury Group, Sao Paulo, São Paulo, Brazil

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Letícia Ferro Leal Department of Pediatrics, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, São Paulo, Brazil

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Carlos Eduardo Martinelli Department of Pediatrics, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, São Paulo, Brazil

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Margaret de Castro Department of Internal Medicine, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, São Paulo, Brazil

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Silvio Tucci Department of Surgery, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, São Paulo, Brazil

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Luciano Neder Department of Pathology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, São Paulo, Brazil

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Leandra Ramalho Department of Pathology, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, São Paulo, Brazil

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Ana Luiza Seidinger Boldrini Children Center, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil

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Izilda Cardinalli Boldrini Children Center, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil

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Maria José Mastellaro Boldrini Children Center, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil

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José Andres Yunes Boldrini Children Center, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil
State University of Campinas (UNICAMP), CampinasSão Paulo, Brazil

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Silvia Regina Brandalise Boldrini Children Center, State University of Campinas (UNICAMP), Campinas, São Paulo, Brazil
State University of Campinas (UNICAMP), CampinasSão Paulo, Brazil

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Luiz Gonzaga Tone Department of Pediatrics, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, São Paulo, Brazil

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Sonir Roberto Rauber Antonini Department of Pediatrics, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, São Paulo, Brazil

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Carlos Alberto Scrideli Department of Pediatrics, Ribeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, São Paulo, Brazil

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steroidogenesis ( Samandari et al. 2007 ). To a lesser extent, only testosterone concentration was significantly reduced after OSI-906 treatment, suggesting that steroidogenesis impairment STARted with lower STAR protein expression could not be sufficient to

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Lucia Gagliardi Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia

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King-Hwa Ling Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia

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Chung H Kok Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia

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Joseph Carolan Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia

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Peter Brautigan Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia

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Rosalie Kenyon Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia

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Richard J D'Andrea Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia

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Mark Van der Hoek Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia

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Christopher N Hahn Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia

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David J Torpy Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia

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Hamish S Scott Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia

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of AIMAH, ascribed to differential localisation of steroidogenic enzymes in clear and compact cells, resulting in inefficient steroidogenesis ( Lacroix 2009 ). Thus, CS is the result of hypercortisolism due to a colossal increase in adrenocortical

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Isadora P Cavalcante Université de Paris, Institut Cochin, INSERM, CNRS, Paris, France

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Marthe Rizk-Rabin Université de Paris, Institut Cochin, INSERM, CNRS, Paris, France

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Christopher Ribes Université de Paris, Institut Cochin, INSERM, CNRS, Paris, France

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Karine Perlemoine Université de Paris, Institut Cochin, INSERM, CNRS, Paris, France

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Constanze Hantel Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ), University of Zurich (UZH), Zurich, Switzerland
Medizinische Klinik und Poliklinik III, University Hospital Carl Gustav Carus Dresden, Dresden, Germany

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Annabel Berthon Université de Paris, Institut Cochin, INSERM, CNRS, Paris, France

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Jérôme Bertherat Université de Paris, Institut Cochin, INSERM, CNRS, Paris, France
Department of Endocrinology and National Reference Center for Rare Adrenal Disorders, Hôpital Cochin, Assistance Publique Hôpitaux de Paris, Paris, France

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Bruno Ragazzon Université de Paris, Institut Cochin, INSERM, CNRS, Paris, France

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uniformly distributed in the cytoplasm ( Berthon et al. 2017 a ). The function of ARMC5 is poorly known, aside from the fact that it regulates cell death and adrenal steroidogenesis in vitro ( Assie et al. 2013 , Cavalcante et al. 2018 ). Armc5

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Carole Guerin Aix-Marseille University, Aix-Marseille University, Department of Nuclear Medicine, Aix-Marseille University, Endocrine Division, Assistance Publique Hopitaux de Marseille, Department of Endocrine Surgery, La Conception Hospital, Marseille, France

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David Taieb Aix-Marseille University, Aix-Marseille University, Department of Nuclear Medicine, Aix-Marseille University, Endocrine Division, Assistance Publique Hopitaux de Marseille, Department of Endocrine Surgery, La Conception Hospital, Marseille, France

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Giorgio Treglia Aix-Marseille University, Aix-Marseille University, Department of Nuclear Medicine, Aix-Marseille University, Endocrine Division, Assistance Publique Hopitaux de Marseille, Department of Endocrine Surgery, La Conception Hospital, Marseille, France

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Thierry Brue Aix-Marseille University, Aix-Marseille University, Department of Nuclear Medicine, Aix-Marseille University, Endocrine Division, Assistance Publique Hopitaux de Marseille, Department of Endocrine Surgery, La Conception Hospital, Marseille, France

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André Lacroix Aix-Marseille University, Aix-Marseille University, Department of Nuclear Medicine, Aix-Marseille University, Endocrine Division, Assistance Publique Hopitaux de Marseille, Department of Endocrine Surgery, La Conception Hospital, Marseille, France

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Frederic Sebag Aix-Marseille University, Aix-Marseille University, Department of Nuclear Medicine, Aix-Marseille University, Endocrine Division, Assistance Publique Hopitaux de Marseille, Department of Endocrine Surgery, La Conception Hospital, Marseille, France

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Frederic Castinetti Aix-Marseille University, Aix-Marseille University, Department of Nuclear Medicine, Aix-Marseille University, Endocrine Division, Assistance Publique Hopitaux de Marseille, Department of Endocrine Surgery, La Conception Hospital, Marseille, France

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(BA) to cure hypercortisolism ( Lacroix et al . 2015 , Nieman et al . 2015 ). The recent Endocrine Society Guidelines have not recommended BA as a first-line treatment of CS ( Nieman et al . 2015 ). Long-term efficacy and safety of steroidogenesis

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Ségolène Hescot INSERM U693, UMR-S693, Assistance Publique-Hôpitaux de Paris, INSERM UMRS 1016, Service Interdépartemental de Pharmacologie et d'Analyse du Médicament, Oncologie Endocrinienne, HRA Pharma, Assistance Publique-Hôpitaux de Paris, Assistance Publique-Hôpitaux de Paris, Fac Med Paris Sud, Rue Gabriel Péri, Le Kremlin-Bicêtre F-94276, France
INSERM U693, UMR-S693, Assistance Publique-Hôpitaux de Paris, INSERM UMRS 1016, Service Interdépartemental de Pharmacologie et d'Analyse du Médicament, Oncologie Endocrinienne, HRA Pharma, Assistance Publique-Hôpitaux de Paris, Assistance Publique-Hôpitaux de Paris, Fac Med Paris Sud, Rue Gabriel Péri, Le Kremlin-Bicêtre F-94276, France

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Abdelhamid Slama INSERM U693, UMR-S693, Assistance Publique-Hôpitaux de Paris, INSERM UMRS 1016, Service Interdépartemental de Pharmacologie et d'Analyse du Médicament, Oncologie Endocrinienne, HRA Pharma, Assistance Publique-Hôpitaux de Paris, Assistance Publique-Hôpitaux de Paris, Fac Med Paris Sud, Rue Gabriel Péri, Le Kremlin-Bicêtre F-94276, France

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Anne Lombès INSERM U693, UMR-S693, Assistance Publique-Hôpitaux de Paris, INSERM UMRS 1016, Service Interdépartemental de Pharmacologie et d'Analyse du Médicament, Oncologie Endocrinienne, HRA Pharma, Assistance Publique-Hôpitaux de Paris, Assistance Publique-Hôpitaux de Paris, Fac Med Paris Sud, Rue Gabriel Péri, Le Kremlin-Bicêtre F-94276, France

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Angelo Paci INSERM U693, UMR-S693, Assistance Publique-Hôpitaux de Paris, INSERM UMRS 1016, Service Interdépartemental de Pharmacologie et d'Analyse du Médicament, Oncologie Endocrinienne, HRA Pharma, Assistance Publique-Hôpitaux de Paris, Assistance Publique-Hôpitaux de Paris, Fac Med Paris Sud, Rue Gabriel Péri, Le Kremlin-Bicêtre F-94276, France

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Hervé Remy INSERM U693, UMR-S693, Assistance Publique-Hôpitaux de Paris, INSERM UMRS 1016, Service Interdépartemental de Pharmacologie et d'Analyse du Médicament, Oncologie Endocrinienne, HRA Pharma, Assistance Publique-Hôpitaux de Paris, Assistance Publique-Hôpitaux de Paris, Fac Med Paris Sud, Rue Gabriel Péri, Le Kremlin-Bicêtre F-94276, France

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Sophie Leboulleux INSERM U693, UMR-S693, Assistance Publique-Hôpitaux de Paris, INSERM UMRS 1016, Service Interdépartemental de Pharmacologie et d'Analyse du Médicament, Oncologie Endocrinienne, HRA Pharma, Assistance Publique-Hôpitaux de Paris, Assistance Publique-Hôpitaux de Paris, Fac Med Paris Sud, Rue Gabriel Péri, Le Kremlin-Bicêtre F-94276, France

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Rita Chadarevian INSERM U693, UMR-S693, Assistance Publique-Hôpitaux de Paris, INSERM UMRS 1016, Service Interdépartemental de Pharmacologie et d'Analyse du Médicament, Oncologie Endocrinienne, HRA Pharma, Assistance Publique-Hôpitaux de Paris, Assistance Publique-Hôpitaux de Paris, Fac Med Paris Sud, Rue Gabriel Péri, Le Kremlin-Bicêtre F-94276, France

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Séverine Trabado INSERM U693, UMR-S693, Assistance Publique-Hôpitaux de Paris, INSERM UMRS 1016, Service Interdépartemental de Pharmacologie et d'Analyse du Médicament, Oncologie Endocrinienne, HRA Pharma, Assistance Publique-Hôpitaux de Paris, Assistance Publique-Hôpitaux de Paris, Fac Med Paris Sud, Rue Gabriel Péri, Le Kremlin-Bicêtre F-94276, France
INSERM U693, UMR-S693, Assistance Publique-Hôpitaux de Paris, INSERM UMRS 1016, Service Interdépartemental de Pharmacologie et d'Analyse du Médicament, Oncologie Endocrinienne, HRA Pharma, Assistance Publique-Hôpitaux de Paris, Assistance Publique-Hôpitaux de Paris, Fac Med Paris Sud, Rue Gabriel Péri, Le Kremlin-Bicêtre F-94276, France
INSERM U693, UMR-S693, Assistance Publique-Hôpitaux de Paris, INSERM UMRS 1016, Service Interdépartemental de Pharmacologie et d'Analyse du Médicament, Oncologie Endocrinienne, HRA Pharma, Assistance Publique-Hôpitaux de Paris, Assistance Publique-Hôpitaux de Paris, Fac Med Paris Sud, Rue Gabriel Péri, Le Kremlin-Bicêtre F-94276, France

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Larbi Amazit INSERM U693, UMR-S693, Assistance Publique-Hôpitaux de Paris, INSERM UMRS 1016, Service Interdépartemental de Pharmacologie et d'Analyse du Médicament, Oncologie Endocrinienne, HRA Pharma, Assistance Publique-Hôpitaux de Paris, Assistance Publique-Hôpitaux de Paris, Fac Med Paris Sud, Rue Gabriel Péri, Le Kremlin-Bicêtre F-94276, France
INSERM U693, UMR-S693, Assistance Publique-Hôpitaux de Paris, INSERM UMRS 1016, Service Interdépartemental de Pharmacologie et d'Analyse du Médicament, Oncologie Endocrinienne, HRA Pharma, Assistance Publique-Hôpitaux de Paris, Assistance Publique-Hôpitaux de Paris, Fac Med Paris Sud, Rue Gabriel Péri, Le Kremlin-Bicêtre F-94276, France

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Jacques Young INSERM U693, UMR-S693, Assistance Publique-Hôpitaux de Paris, INSERM UMRS 1016, Service Interdépartemental de Pharmacologie et d'Analyse du Médicament, Oncologie Endocrinienne, HRA Pharma, Assistance Publique-Hôpitaux de Paris, Assistance Publique-Hôpitaux de Paris, Fac Med Paris Sud, Rue Gabriel Péri, Le Kremlin-Bicêtre F-94276, France
INSERM U693, UMR-S693, Assistance Publique-Hôpitaux de Paris, INSERM UMRS 1016, Service Interdépartemental de Pharmacologie et d'Analyse du Médicament, Oncologie Endocrinienne, HRA Pharma, Assistance Publique-Hôpitaux de Paris, Assistance Publique-Hôpitaux de Paris, Fac Med Paris Sud, Rue Gabriel Péri, Le Kremlin-Bicêtre F-94276, France
INSERM U693, UMR-S693, Assistance Publique-Hôpitaux de Paris, INSERM UMRS 1016, Service Interdépartemental de Pharmacologie et d'Analyse du Médicament, Oncologie Endocrinienne, HRA Pharma, Assistance Publique-Hôpitaux de Paris, Assistance Publique-Hôpitaux de Paris, Fac Med Paris Sud, Rue Gabriel Péri, Le Kremlin-Bicêtre F-94276, France

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Eric Baudin INSERM U693, UMR-S693, Assistance Publique-Hôpitaux de Paris, INSERM UMRS 1016, Service Interdépartemental de Pharmacologie et d'Analyse du Médicament, Oncologie Endocrinienne, HRA Pharma, Assistance Publique-Hôpitaux de Paris, Assistance Publique-Hôpitaux de Paris, Fac Med Paris Sud, Rue Gabriel Péri, Le Kremlin-Bicêtre F-94276, France
INSERM U693, UMR-S693, Assistance Publique-Hôpitaux de Paris, INSERM UMRS 1016, Service Interdépartemental de Pharmacologie et d'Analyse du Médicament, Oncologie Endocrinienne, HRA Pharma, Assistance Publique-Hôpitaux de Paris, Assistance Publique-Hôpitaux de Paris, Fac Med Paris Sud, Rue Gabriel Péri, Le Kremlin-Bicêtre F-94276, France
INSERM U693, UMR-S693, Assistance Publique-Hôpitaux de Paris, INSERM UMRS 1016, Service Interdépartemental de Pharmacologie et d'Analyse du Médicament, Oncologie Endocrinienne, HRA Pharma, Assistance Publique-Hôpitaux de Paris, Assistance Publique-Hôpitaux de Paris, Fac Med Paris Sud, Rue Gabriel Péri, Le Kremlin-Bicêtre F-94276, France

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Marc Lombès INSERM U693, UMR-S693, Assistance Publique-Hôpitaux de Paris, INSERM UMRS 1016, Service Interdépartemental de Pharmacologie et d'Analyse du Médicament, Oncologie Endocrinienne, HRA Pharma, Assistance Publique-Hôpitaux de Paris, Assistance Publique-Hôpitaux de Paris, Fac Med Paris Sud, Rue Gabriel Péri, Le Kremlin-Bicêtre F-94276, France
INSERM U693, UMR-S693, Assistance Publique-Hôpitaux de Paris, INSERM UMRS 1016, Service Interdépartemental de Pharmacologie et d'Analyse du Médicament, Oncologie Endocrinienne, HRA Pharma, Assistance Publique-Hôpitaux de Paris, Assistance Publique-Hôpitaux de Paris, Fac Med Paris Sud, Rue Gabriel Péri, Le Kremlin-Bicêtre F-94276, France
INSERM U693, UMR-S693, Assistance Publique-Hôpitaux de Paris, INSERM UMRS 1016, Service Interdépartemental de Pharmacologie et d'Analyse du Médicament, Oncologie Endocrinienne, HRA Pharma, Assistance Publique-Hôpitaux de Paris, Assistance Publique-Hôpitaux de Paris, Fac Med Paris Sud, Rue Gabriel Péri, Le Kremlin-Bicêtre F-94276, France

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selectively on the adrenal cortex where it has a cytotoxic effect and impairs steroidogenesis ( Bergenstal & Dao 1953 ). Mitotane is a part of the reference treatment of advanced ACC ( Berruti 2012 , Fassnacht et al . 2012 ). Indeed, it remains the single

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