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Department of Cancer Biology, Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, 233 S 10th Street, BLSB 1008, Philadelphia, Pennsylvania 19107, USA
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Department of Cancer Biology, Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, 233 S 10th Street, BLSB 1008, Philadelphia, Pennsylvania 19107, USA
Department of Cancer Biology, Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, 233 S 10th Street, BLSB 1008, Philadelphia, Pennsylvania 19107, USA
Department of Cancer Biology, Department of Urology, Kimmel Cancer Center, Thomas Jefferson University, 233 S 10th Street, BLSB 1008, Philadelphia, Pennsylvania 19107, USA
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et al . (2013) , published in the April 2013 issue of Endocrine-Related Cancer , IGF2 was unexpectedly identified as a key factor able to induce de novo steroidogenesis in prostate cancer cells. Notably, high levels of IGF2 have been implicated
Institute of Health and Biomedical Innovation, Vancouver Prostate Centre, Departments of Medicine and Oncology, Australian Prostate Cancer Research Centre – Queensland, Princess Alexandra Hospital, Queensland University of Technology, Level 1, Building 1, 199 Ipswich Road, Brisbane, Queensland 4102, Australia
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Institute of Health and Biomedical Innovation, Vancouver Prostate Centre, Departments of Medicine and Oncology, Australian Prostate Cancer Research Centre – Queensland, Princess Alexandra Hospital, Queensland University of Technology, Level 1, Building 1, 199 Ipswich Road, Brisbane, Queensland 4102, Australia
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receptors or increase AR sensitivity to low androgen and drive progression ( Stanbrough et al . 2006 , Locke et al . 2008 ). We recently reported that insulin, which rises in response to ADT, can drive expression of steroidogenesis enzymes in PC cells
Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
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Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
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Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
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Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
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Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
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Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
Olson Center for Women's Health, Department of Obstetrics and Gynecology, The Fred and Pamela Buffett Cancer Center, Department of Pathology, Department of Ophthalmology and Visual Science, Department of Pathology, Omaha Veterans Affairs Medical Center, College of Animal Science and Technology
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regulation of GCT cell proliferation, migration, and steroidogenesis using the KGN human GCT cell line as a cellular model. Our results indicate that the Hippo/YAP signaling pathway plays a critical role in the regulation of GCT progression. Materials and
Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada
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Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada
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Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada
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Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada
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Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada
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Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada
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poorly understood. This study is a step toward unraveling the signaling programs that affect steroidogenesis in PCa cells. Several lines of evidence suggest that activation of various receptor tyrosine kinase (RTK) pathways can stimulate steroidogenesis
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Center for One Medicine Innovative Translational Research (COMIT), Gifu University, Gifu, Japan
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steroidogenic enzymes, including HSD3B1 , in prostate cancer cells, supporting the contribution of steroidogenesis upregulation to tumor growth at the bone-metastatic site ( Hagberg Thulin et al. 2016 , Huang et al. 2021 ). Figure 2 Schematic
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State University of Campinas (UNICAMP), CampinasSão Paulo, Brazil
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State University of Campinas (UNICAMP), CampinasSão Paulo, Brazil
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steroidogenesis ( Samandari et al. 2007 ). To a lesser extent, only testosterone concentration was significantly reduced after OSI-906 treatment, suggesting that steroidogenesis impairment STARted with lower STAR protein expression could not be sufficient to
Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
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Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
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Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
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Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
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Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
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Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
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Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
Endocrine and Metabolic Unit, School of Medicine, Department of Obstetrics and Gynaecology, Haematology, Molecular Pathology, Adelaide Microarray Centre, School of Molecular and Biomedical Science, Centre for Stem Cell Research, Haematology and Oncology Department, Royal Adelaide Hospital, Adelaide, South Australia 5000, Australia
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of AIMAH, ascribed to differential localisation of steroidogenic enzymes in clear and compact cells, resulting in inefficient steroidogenesis ( Lacroix 2009 ). Thus, CS is the result of hypercortisolism due to a colossal increase in adrenocortical
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Medizinische Klinik und Poliklinik III, University Hospital Carl Gustav Carus Dresden, Dresden, Germany
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Department of Endocrinology and National Reference Center for Rare Adrenal Disorders, Hôpital Cochin, Assistance Publique Hôpitaux de Paris, Paris, France
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uniformly distributed in the cytoplasm ( Berthon et al. 2017 a ). The function of ARMC5 is poorly known, aside from the fact that it regulates cell death and adrenal steroidogenesis in vitro ( Assie et al. 2013 , Cavalcante et al. 2018 ). Armc5
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(BA) to cure hypercortisolism ( Lacroix et al . 2015 , Nieman et al . 2015 ). The recent Endocrine Society Guidelines have not recommended BA as a first-line treatment of CS ( Nieman et al . 2015 ). Long-term efficacy and safety of steroidogenesis
INSERM U693, UMR-S693, Assistance Publique-Hôpitaux de Paris, INSERM UMRS 1016, Service Interdépartemental de Pharmacologie et d'Analyse du Médicament, Oncologie Endocrinienne, HRA Pharma, Assistance Publique-Hôpitaux de Paris, Assistance Publique-Hôpitaux de Paris, Fac Med Paris Sud, Rue Gabriel Péri, Le Kremlin-Bicêtre F-94276, France
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INSERM U693, UMR-S693, Assistance Publique-Hôpitaux de Paris, INSERM UMRS 1016, Service Interdépartemental de Pharmacologie et d'Analyse du Médicament, Oncologie Endocrinienne, HRA Pharma, Assistance Publique-Hôpitaux de Paris, Assistance Publique-Hôpitaux de Paris, Fac Med Paris Sud, Rue Gabriel Péri, Le Kremlin-Bicêtre F-94276, France
INSERM U693, UMR-S693, Assistance Publique-Hôpitaux de Paris, INSERM UMRS 1016, Service Interdépartemental de Pharmacologie et d'Analyse du Médicament, Oncologie Endocrinienne, HRA Pharma, Assistance Publique-Hôpitaux de Paris, Assistance Publique-Hôpitaux de Paris, Fac Med Paris Sud, Rue Gabriel Péri, Le Kremlin-Bicêtre F-94276, France
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INSERM U693, UMR-S693, Assistance Publique-Hôpitaux de Paris, INSERM UMRS 1016, Service Interdépartemental de Pharmacologie et d'Analyse du Médicament, Oncologie Endocrinienne, HRA Pharma, Assistance Publique-Hôpitaux de Paris, Assistance Publique-Hôpitaux de Paris, Fac Med Paris Sud, Rue Gabriel Péri, Le Kremlin-Bicêtre F-94276, France
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INSERM U693, UMR-S693, Assistance Publique-Hôpitaux de Paris, INSERM UMRS 1016, Service Interdépartemental de Pharmacologie et d'Analyse du Médicament, Oncologie Endocrinienne, HRA Pharma, Assistance Publique-Hôpitaux de Paris, Assistance Publique-Hôpitaux de Paris, Fac Med Paris Sud, Rue Gabriel Péri, Le Kremlin-Bicêtre F-94276, France
INSERM U693, UMR-S693, Assistance Publique-Hôpitaux de Paris, INSERM UMRS 1016, Service Interdépartemental de Pharmacologie et d'Analyse du Médicament, Oncologie Endocrinienne, HRA Pharma, Assistance Publique-Hôpitaux de Paris, Assistance Publique-Hôpitaux de Paris, Fac Med Paris Sud, Rue Gabriel Péri, Le Kremlin-Bicêtre F-94276, France
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INSERM U693, UMR-S693, Assistance Publique-Hôpitaux de Paris, INSERM UMRS 1016, Service Interdépartemental de Pharmacologie et d'Analyse du Médicament, Oncologie Endocrinienne, HRA Pharma, Assistance Publique-Hôpitaux de Paris, Assistance Publique-Hôpitaux de Paris, Fac Med Paris Sud, Rue Gabriel Péri, Le Kremlin-Bicêtre F-94276, France
INSERM U693, UMR-S693, Assistance Publique-Hôpitaux de Paris, INSERM UMRS 1016, Service Interdépartemental de Pharmacologie et d'Analyse du Médicament, Oncologie Endocrinienne, HRA Pharma, Assistance Publique-Hôpitaux de Paris, Assistance Publique-Hôpitaux de Paris, Fac Med Paris Sud, Rue Gabriel Péri, Le Kremlin-Bicêtre F-94276, France
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INSERM U693, UMR-S693, Assistance Publique-Hôpitaux de Paris, INSERM UMRS 1016, Service Interdépartemental de Pharmacologie et d'Analyse du Médicament, Oncologie Endocrinienne, HRA Pharma, Assistance Publique-Hôpitaux de Paris, Assistance Publique-Hôpitaux de Paris, Fac Med Paris Sud, Rue Gabriel Péri, Le Kremlin-Bicêtre F-94276, France
INSERM U693, UMR-S693, Assistance Publique-Hôpitaux de Paris, INSERM UMRS 1016, Service Interdépartemental de Pharmacologie et d'Analyse du Médicament, Oncologie Endocrinienne, HRA Pharma, Assistance Publique-Hôpitaux de Paris, Assistance Publique-Hôpitaux de Paris, Fac Med Paris Sud, Rue Gabriel Péri, Le Kremlin-Bicêtre F-94276, France
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selectively on the adrenal cortex where it has a cytotoxic effect and impairs steroidogenesis ( Bergenstal & Dao 1953 ). Mitotane is a part of the reference treatment of advanced ACC ( Berruti 2012 , Fassnacht et al . 2012 ). Indeed, it remains the single