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Thomas G Papathomas, Lindsey Oudijk, Ellen C Zwarthoff, Edward Post, Floor A Duijkers, Max M van Noesel, Leo J Hofland, Patrick J Pollard, Eamonn R Maher, David F Restuccia, Richard A Feelders, Gaston J H Franssen, Henri J Timmers, Stefan Sleijfer, Wouter W de Herder, Ronald R de Krijger, Winand N M Dinjens and Esther Korpershoek

Introduction Telomerase is a ribonucleoprotein complex consisting of the telomerase reverse transcriptase (TERT) catalytic subunit and the telomerase RNA component. Telomerase is responsible for the addition of telomeric repeats at the end of linear

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Annamaria Biroccio and Carlo Leonetti

senescence. By contrast, immortal cells as well as germline cells adopt some mechanisms to bypass the senescence checkpoint. Telomere maintenance in 80–95% of tumor cells is achieved by telomerase, a reverse transcriptase enzyme that catalyzes the synthesis

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Tiantian Liu, Taylor C Brown, C Christofer Juhlin, Adam Andreasson, Na Wang, Martin Bäckdahl, James M Healy, Manju L Prasad, Reju Korah, Tobias Carling, Dawei Xu and Catharina Larsson

telomerase reverse transcriptase (TERT), a catalytic subunit of the telomerase enzyme complex. As the de-repression of TERT gene transcription is intimately coupled with the acquisition of telomerase activity in transformed cells, regulatory mechanisms

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Johan O Paulsson, Ninni Mu, Ivan Shabo, Na Wang, Jan Zedenius, Catharina Larsson and C Christofer Juhlin

Introduction The telomerase enzyme consists of a protein component with reverse transcriptase activity, encoded by the telomerase reverse transcriptase ( TERT ) gene ( Cong et al. 2002 ). Telomerase activation is a hallmark of malignant

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Rengyun Liu and Mingzhao Xing

Introduction Telomerase reverse transcriptase in human cancer Telomerase reverse transcriptase (TERT) is the catalytic protein subunit of telomerase, which, together with an integral RNA subunit and several species-specific assessor proteins

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Ji Won Kim, Dharmendra K Yadav, Soo Jin Kim, Moo-Yeol Lee, Jung-Min Park, Bum Seok Kim, Mi-hyun Kim, Hyeung-geun Park and Keon Wook Kang

Introduction GV1001 is a peptide composed of 16 amino acids derived from the human telomerase reverse transcriptase catalytic subunit (hTERT). It has been developed as an injectable formulation of cancer vaccine for immunotherapy of many types

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Ebtesam Qasem, Avaniyapuram Kannan Murugan, Hindi Al-Hindi, Mingzhao Xing, Mai Almohanna, Meshael Alswailem and Ali S Alzahrani

reverse transcriptase ( TERT) promoter ( Landa et al . 2013 , Liu et al . 2013 , 2014 a , Vinagre et al . 2013 , Liu & Xing 2014 , Melo et al . 2014 , Ngeow & Eng 2014 , Wang et al . 2014 a , Xing et al . 2014 , Gandolfi et al . 2015

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Rengyun Liu and Mingzhao Xing

required to achieve this. Two recently discovered mutations in the promoter of the gene for telomerase reverse transcriptase (TERT) in thyroid cancer show promise in this regard – chr5:1 295 228C>T and chr5:1 295 250C>T (termed herein as C228T and C250T

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Xiaoli Liu, Justin Bishop, Yuan Shan, Sara Pai, Dingxie Liu, Avaniyapuram Kannan Murugan, Hui Sun, Adel K El-Naggar and Mingzhao Xing

telomerase reverse transcriptase (TERT). Promoter mutations in the TERT gene on chromosome 5 have recently been reported in melanomas ( Horn et al . 2013 , Huang et al . 2013 ). Two TERT promoter mutations, 1 295 228 C>T and 1 295 250 C>T (termed C228T

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Matthias S Dettmer, Anja Schmitt, Hans Steinert, David Capper, Holger Moch, Paul Komminoth and Aurel Perren

have an adverse outcome in consecutive clinicopathological series, and this has led to very small groups of high-risk tumors with limited statistical power in different studies ( Handkiewicz-Junak et al . 2010 ). Reactivation of the telomerase reverse