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Seog Yun Park Center for Thyroid Cancer, Center for Lung Cancer, Research Institute, Department of Otolaryngology‐Head and Neck Surgery

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Yuh-S Jung Center for Thyroid Cancer, Center for Lung Cancer, Research Institute, Department of Otolaryngology‐Head and Neck Surgery

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Chang Hwan Ryu Center for Thyroid Cancer, Center for Lung Cancer, Research Institute, Department of Otolaryngology‐Head and Neck Surgery

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Chang Yoon Lee Center for Thyroid Cancer, Center for Lung Cancer, Research Institute, Department of Otolaryngology‐Head and Neck Surgery

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You Jin Lee Center for Thyroid Cancer, Center for Lung Cancer, Research Institute, Department of Otolaryngology‐Head and Neck Surgery

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Eun Kyung Lee Center for Thyroid Cancer, Center for Lung Cancer, Research Institute, Department of Otolaryngology‐Head and Neck Surgery

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Seok-Ki Kim Center for Thyroid Cancer, Center for Lung Cancer, Research Institute, Department of Otolaryngology‐Head and Neck Surgery

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Tae Sung Kim Center for Thyroid Cancer, Center for Lung Cancer, Research Institute, Department of Otolaryngology‐Head and Neck Surgery

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Tae Hyun Kim Center for Thyroid Cancer, Center for Lung Cancer, Research Institute, Department of Otolaryngology‐Head and Neck Surgery

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Jeyun Jang Center for Thyroid Cancer, Center for Lung Cancer, Research Institute, Department of Otolaryngology‐Head and Neck Surgery

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Daeyoon Park Center for Thyroid Cancer, Center for Lung Cancer, Research Institute, Department of Otolaryngology‐Head and Neck Surgery

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Seung Myung Dong Center for Thyroid Cancer, Center for Lung Cancer, Research Institute, Department of Otolaryngology‐Head and Neck Surgery

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Jae-Goo Kang Center for Thyroid Cancer, Center for Lung Cancer, Research Institute, Department of Otolaryngology‐Head and Neck Surgery

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Jin Soo Lee Center for Thyroid Cancer, Center for Lung Cancer, Research Institute, Department of Otolaryngology‐Head and Neck Surgery

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Junsun Ryu Center for Thyroid Cancer, Center for Lung Cancer, Research Institute, Department of Otolaryngology‐Head and Neck Surgery

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Introduction Thyroid cancer is the most common endocrine cancer worldwide, and its incidence is increasing. In 2012, thyroid cancer was the most common malignancy in Korea, with an annual incidence of 87/100 000 people ( Jung et al . 2015

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Soomin Ahn Department of Pathology, Ewha Womans University School of Medicine, Seoul, Korea

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Tae Hyuk Kim Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Sun Wook Kim Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Chang Seok Ki Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Hye Won Jang Department of Medical Education, Sungkyunkwan University School of Medicine, Seoul, Korea

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Jee Soo Kim Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Jung Han Kim Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Jun-Ho Choe Division of Breast and Endocrine Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Jung Hee Shin Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Soo Yeon Hahn Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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Young Lyun Oh Department of Pathology and Translational genomics, Sungkyunkwan University School of Medicine, Seoul, Korea

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Jae Hoon Chung Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea

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. There have been several studies investigating PD-L1 expression in thyroid cancer ( Cunha et al. 2013 , Angell et al. 2014 , Wu et al. 2015 , Bastman et al. 2016 , Chowdhury et al. 2016 ). The frequency of PD-L1 positivity ranges from 23% to

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Huy Gia Vuong Department of Pathology, Oklahoma University Health Sciences Center, Oklahoma City, Oklahoma, USA

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Truong P X Nguyen Department of Pathology, Cho Ray Hospital, Ho Chi Minh, Vietnam

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Hanh T T Ngo Department of Pathology, University of Medicine and Pharmacy, Ho Chi Minh, Vietnam

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Lewis Hassell Department of Pathology, Oklahoma University Health Sciences Center, Oklahoma City, Oklahoma, USA

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Kennichi Kakudo Department of Pathology and Thyroid Disease Center, Izumi City General Hospital, Izumi-city, Wake-cho, Japan

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locations of head and neck malignant teratomas are the soft tissue of the head and neck (56%), followed by the thyroid gland (13%) ( Ramsey et al. 2021 ). Primary malignant thyroid teratomas (MTT) are very rare neoplasms with about 40 cases reported in

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Fadi Nabhan Division of Endocrinology, Diabetes and Metabolism, The Ohio State University College of Medicine, Wexner Medical Center, Arthur G. James Comprehensive Cancer Center, Columbus, Ohio, USA

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Matthew D Ringel Division of Endocrinology, Diabetes and Metabolism, The Ohio State University College of Medicine, Wexner Medical Center, Arthur G. James Comprehensive Cancer Center, Columbus, Ohio, USA

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Introduction Thyroid cancer is one of the most prevalent solid tumor types throughout the world with a rising incidence, particularly in women ( Davies & Welch 2014 ). The range of prognosis for patients with thyroid cancer is highly variable

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Kyoungjune Pak Department of Nuclear Medicine, Department of Internal Medicine, Medical Research Institute
Department of Nuclear Medicine, Department of Internal Medicine, Medical Research Institute

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Seong-Jang Kim Department of Nuclear Medicine, Department of Internal Medicine, Medical Research Institute
Department of Nuclear Medicine, Department of Internal Medicine, Medical Research Institute

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In Joo Kim Department of Nuclear Medicine, Department of Internal Medicine, Medical Research Institute
Department of Nuclear Medicine, Department of Internal Medicine, Medical Research Institute

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Bo Hyun Kim Department of Nuclear Medicine, Department of Internal Medicine, Medical Research Institute
Department of Nuclear Medicine, Department of Internal Medicine, Medical Research Institute

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Sang Soo Kim Department of Nuclear Medicine, Department of Internal Medicine, Medical Research Institute
Department of Nuclear Medicine, Department of Internal Medicine, Medical Research Institute

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Yun Kyung Jeon Department of Nuclear Medicine, Department of Internal Medicine, Medical Research Institute
Department of Nuclear Medicine, Department of Internal Medicine, Medical Research Institute

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Introduction Thyroid nodules are common and can be detected incidentally in 27–67% of individuals ( Brander et al . 1991 , Ezzat et al . 1994 ). However, only 1 in 20 palpable nodules is malignant ( Mazzaferri 1992 ). How can we detect cancer

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Jae Hyun Park Department of Surgery, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, South Korea

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Jong Ho Yoon Department of Surgery, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, Wonju, South Korea

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Introduction Surgical treatment for a differentiated thyroid carcinoma (DTC) derived from follicular cells is a starting point of a multifaceted treatment approach. Even though DTC is generally non-aggressive and has good prognosis, choosing

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Kirk Jensen Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA

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Athanasios Bikas Department of Internal Medicine, Georgetown University Hospital MedStar, Washington Hospital Center Internal Medicine Residency Program, Washington, District of Columbia, USA

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Aneeta Patel Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA

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Yevgeniya Kushchayeva National Institutes of Health, NIDDK, Bethesda, Maryland, USA

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John Costello Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA

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Dennis McDaniel Uniformed Services University of the Health Sciences, Biomedical Instrumentation Center, Bethesda, Maryland, USA

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Kenneth Burman MedStar Washington Hospital Center, Endocrinology, Washington, District of Columbia, USA

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Vasyl Vasko Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA

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Introduction Thyroid cancer is the most common endocrine malignancy ( Hundahl et al . 1998 ) and is also increasing at the fastest incidence rate of any malignancy ( Morris et al . 2016 ). Patients with differentiated thyroid cancer have an

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Ebtesam Qasem Department of Molecular Oncology, Department of Pathology and Laboratory Medicine, Department of Medicine, Division of Endocrinology and Metabolism, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

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Avaniyapuram Kannan Murugan Department of Molecular Oncology, Department of Pathology and Laboratory Medicine, Department of Medicine, Division of Endocrinology and Metabolism, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

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Hindi Al-Hindi Department of Molecular Oncology, Department of Pathology and Laboratory Medicine, Department of Medicine, Division of Endocrinology and Metabolism, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

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Mingzhao Xing Department of Molecular Oncology, Department of Pathology and Laboratory Medicine, Department of Medicine, Division of Endocrinology and Metabolism, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

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Mai Almohanna Department of Molecular Oncology, Department of Pathology and Laboratory Medicine, Department of Medicine, Division of Endocrinology and Metabolism, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

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Meshael Alswailem Department of Molecular Oncology, Department of Pathology and Laboratory Medicine, Department of Medicine, Division of Endocrinology and Metabolism, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

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Ali S Alzahrani Department of Molecular Oncology, Department of Pathology and Laboratory Medicine, Department of Medicine, Division of Endocrinology and Metabolism, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
Department of Molecular Oncology, Department of Pathology and Laboratory Medicine, Department of Medicine, Division of Endocrinology and Metabolism, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia

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Introduction Differentiated thyroid cancer (DTC) is the most common endocrine malignancy ( Jemal et al . 2011 ). Its incidence has been rapidly increasing over the last four decades ( Jemal et al . 2011 , 2013 , Jung et al . 2014 ). Although

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Tae-Hwan Kim Department of Otorhinolaryngology-Head and Neck Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea

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Mi Yeon Lee Division of Biostatistics, Department of R&D Management, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

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Sung Min Jin Department of Otorhinolaryngology-Head and Neck Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea

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Sang Hyuk Lee Department of Otorhinolaryngology-Head and Neck Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea

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Introduction The incidence of thyroid cancer has been increasing faster than any other malignancy in both women and men ( Chen et al. 2009 ), and it has the highest prevalence among the endocrine malignancies. The etiology of thyroid cancer

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Alfred King-yin Lam Cancer Molecular Pathology, School of Medicine and Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia

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Nassim Saremi Cancer Molecular Pathology, School of Medicine and Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia

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Introduction Cribriform-morular variant of papillary thyroid carcinoma (CMV-PTC) is an uncommon variant of papillary thyroid carcinoma. It is a variant of papillary thyroid carcinoma recognized in the current World Health Organization (WHO

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