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Fiorenza Gianì Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Medical Center, Catania, Italy

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Giuseppe Pandini Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Medical Center, Catania, Italy

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Nunzio Massimo Scalisi Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Medical Center, Catania, Italy

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Paolo Vigneri Medical Oncology and Center of Experimental Oncology and Hematology, Department of Clinical and Experimental Medicine, University of Catania, A.O.U Policlinico Vittorio Emanuele, Catania, Italy

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Carmine Fazzari Humanitas, Catania Oncology Center, Catania, Italy

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Pasqualino Malandrino Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Medical Center, Catania, Italy

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Marco Russo Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Medical Center, Catania, Italy

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Romilda Masucci Surgical Oncology, Garibaldi-Nesima Medical Center, Catania, Italy

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Antonino Belfiore Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Medical Center, Catania, Italy

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Gwabriella Pellegriti Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Medical Center, Catania, Italy

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Riccardo Vigneri Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Medical Center, Catania, Italy
IC Crystallography Institute, National Research Council, CNR, Catania, Italy

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human stem/progenitor thyroid cells (thyrospheres) exposed to the soluble salt sodium tungstate at concentrations in the range of the tungsten levels measured in the urine of residents in the Sicilian volcanic area (nanomolar range, much lower than that

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-19-0176
Volume/Issue:
Volume 26: Issue 8
Free access
Yurong Lu Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu Province, China

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Yuqing Zhao Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu Province, China

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Penggang Liu Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu Province, China

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Xiulong Xu Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu Province, China
Joint International Research Laboratory of Agriculture and Agri-Product Safety of Ministry of Education of China, Yangzhou, Jiangsu Province, China
Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, Jiangsu Province, China

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(1041 bp)-driven luciferase reporter has been recently reported ( Lu et al. 2021 ). Thyrosphere culture SW1736 cells seeded in a six-well plate were incubated in the absence or presence of PLX4032 (2 μM), lapatinib (2 μM), or MK-2206 (10 μM

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-22-0392
Volume/Issue:
Volume 30: Issue 11
Restricted access
Veronica Vella School of Human and Social Sciences, ‘Kore’ University of Enna, Enna, Italy
Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Hospital, Catania, Italy

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Maria Luisa Nicolosi Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Hospital, Catania, Italy

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Patrizia Cantafio Endocrinology, Department of Health Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy

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Michele Massimino Center of Experimental Oncology and Hematology, AOU Policlinico Vittorio Emanuele, Catania, Italy
Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy

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Rosamaria Lappano Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy

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Paolo Vigneri Center of Experimental Oncology and Hematology, AOU Policlinico Vittorio Emanuele, Catania, Italy
Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy

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Roberto Ciuni Unit of Thyroid and Neck Surgery, Policlinico Vittorio Emanuele, University of Catania, Catania, Italy

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Pietro Gangemi Unit of Pathology, Policlinico Vittorio Emanuele, University of Catania, Catania, Italy

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Andrea Morrione Department of Urology and Biology of Prostate Cancer Program, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA

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Roberta Malaguarnera Endocrinology, Department of Health Sciences, University Magna Graecia of Catanzaro, Catanzaro, Italy

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Antonino Belfiore Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Hospital, Catania, Italy

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cancer, IR-A overexpression and autocrine IGF-2 levels were strongly associated with tumor aggressiveness, loss of differentiation ( Vella et al. 2002 ) and with stem-like phenotype and self-renewal when cancer cells were cultured as thyrospheres

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-18-0310
Volume/Issue:
Volume 26: Issue 1
Free access
Antonino Belfiore Endocrinology Unit, Department of Clinical and Experimental Medicine, University Magna Graecia of Catanzaro, Campus Universitario, località Germaneto, 88100 Catanzaro, Italy

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Roberta Malaguarnera Endocrinology Unit, Department of Clinical and Experimental Medicine, University Magna Graecia of Catanzaro, Campus Universitario, località Germaneto, 88100 Catanzaro, Italy

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non-adherent spheres (thyrospheres). In human thyrospheres, we found that IR and IGF1R were markedly overexpressed and with a higher IR:IGF1R ratio compared with primary cultures. The IR:IGF1R ratio was also higher in cancer than in normal thyrospheres

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-11-0074
Volume/Issue:
Volume 18: Issue 4
Free access
Zhenying Guo Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Zhejiang, China

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Heather Hardin Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Zhejiang, China

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Ricardo V Lloyd Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Zhejiang, China

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progenitor cells were able to survive in suspension and produce spherical colonies (thyrospheres) composed of both stem and progenitor cells. Thyrospheres from normal tissue could be induced to differentiate by insulin and insulin-like growth factor

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-14-0002
Volume/Issue:
Volume 21: Issue 5
Free access
Michael Derwahl Department of Medicine, St Hedwig Hospital and Charite, University Medicine Berlin, Grosse Hamburger Straße 5‐11, 10115 Berlin, Germany

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Diana Nicula Department of Medicine, St Hedwig Hospital and Charite, University Medicine Berlin, Grosse Hamburger Straße 5‐11, 10115 Berlin, Germany

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response to intense stimulation with growth factors results in the outgrowth of thyroid stem and progenitor cells as spheroids, designated thyrospheres, in vitro ( Lan et al . 2007 , Fierabracci et al . 2008 , Zheng et al . 2010 ). Very recently, it

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-14-0053
Volume/Issue:
Volume 21: Issue 5
Free access
Christopher W Rowe Department of Endocrinology, John Hunter Hospital, Newcastle, Australia
School of Medicine and Public Health, University of Newcastle, Newcastle, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia

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Jonathan W Paul School of Medicine and Public Health, University of Newcastle, Newcastle, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia

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Craig Gedye Hunter Medical Research Institute, Newcastle, New South Wales, Australia
Department of Medical Oncology, Calvary Mater Newcastle, Waratah, Australia
School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, Australia

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Jorge M Tolosa School of Medicine and Public Health, University of Newcastle, Newcastle, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia

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Cino Bendinelli School of Medicine and Public Health, University of Newcastle, Newcastle, Australia
Department of Surgery, John Hunter Hospital, Newcastle, Australia

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Shaun McGrath Department of Endocrinology, John Hunter Hospital, Newcastle, Australia
School of Medicine and Public Health, University of Newcastle, Newcastle, Australia

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Roger Smith Department of Endocrinology, John Hunter Hospital, Newcastle, Australia
School of Medicine and Public Health, University of Newcastle, Newcastle, Australia
Hunter Medical Research Institute, Newcastle, New South Wales, Australia

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al. 2009 , D'Agostino et al. 2014 , Dotan et al. 2016 ). Similarly, PTC cells grown in thyrosphere culture lack expression of thyroid-specific proteins, and cells fail to produce cAMP in response to TSH stimulation ( Malaguarnera et al. 2011

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-17-0010
Volume/Issue:
Volume 24: Issue 6
Free access