Search Results

You are looking at 1 - 10 of 504 items for :

  • tumor microenvironment x
  • Refine by access: All content x
Clear All
Cassia Michael Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA

Search for other papers by Cassia Michael in
Google Scholar
PubMed
Close
,
Juliana Moreira Mendonça-Gomes Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA

Search for other papers by Juliana Moreira Mendonça-Gomes in
Google Scholar
PubMed
Close
,
Clinton Walton DePaolo Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA

Search for other papers by Clinton Walton DePaolo in
Google Scholar
PubMed
Close
,
Antonio Di Cristofano Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA
Department of Medicine (Oncology), Albert Einstein College of Medicine, Bronx, New York, USA
Montefiore-Einstein Comprehensive Cancer Research Center, Albert Einstein College of Medicine, Bronx, New York, USA
Cancer Dormancy Tumor Microenvironment Institute, Albert Einstein College of Medicine, Bronx, New York, USA

Search for other papers by Antonio Di Cristofano in
Google Scholar
PubMed
Close
, and
Sofia de Oliveira Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, Bronx, New York, USA
Montefiore-Einstein Comprehensive Cancer Research Center, Albert Einstein College of Medicine, Bronx, New York, USA
Cancer Dormancy Tumor Microenvironment Institute, Albert Einstein College of Medicine, Bronx, New York, USA
Department of Medicine (Hepatology), Albert Einstein College of Medicine, Bronx, New York, USA
Marion Bessin Liver Research Center, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA

Search for other papers by Sofia de Oliveira in
Google Scholar
PubMed
Close

xenotransplant model in zebrafish larvae that allows studying thyroid cancer biology and therapeutic response in vivo , including evaluation of the tumor architecture, composition and dynamics of the tumor microenvironment (TME), and the visualization of drug

Restricted access
Thomas Cuny Division Endocrinology, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
Aix-Marseille Université, Institut National de la Santé et de la Recherche Médicale (INSERM), U1251, Marseille Medical Genetics (MMG), Marseille, France
Department of Endocrinology, Assistance Publique – Hôpitaux de Marseille (AP-HM), Hôpital de la Conception, Centre de Référence des Maladies Rares Hypophysaires HYPO, Marseille, France

Search for other papers by Thomas Cuny in
Google Scholar
PubMed
Close
,
Wouter de Herder Division Endocrinology, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

Search for other papers by Wouter de Herder in
Google Scholar
PubMed
Close
,
Anne Barlier Aix-Marseille Université, Institut National de la Santé et de la Recherche Médicale (INSERM), U1251, Marseille Medical Genetics (MMG), Marseille, France
Department of Endocrinology, Assistance Publique – Hôpitaux de Marseille (AP-HM), Hôpital de la Conception, Centre de Référence des Maladies Rares Hypophysaires HYPO, Marseille, France

Search for other papers by Anne Barlier in
Google Scholar
PubMed
Close
, and
Leo J Hofland Division Endocrinology, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands

Search for other papers by Leo J Hofland in
Google Scholar
PubMed
Close

strikingly contrasts with their efficacy in vitro in experimental models ( Kulke 2007 ). Such a discrepancy may, at least partially, arise from influences exerted by the direct microenvironment surrounding the tumor, referred to as the tumor

Free access
Clovis Boibessot Department of Surgery, Laval University, Quebec City, Quebec, Canada

Search for other papers by Clovis Boibessot in
Google Scholar
PubMed
Close
and
Paul Toren Department of Surgery, Laval University, Quebec City, Quebec, Canada

Search for other papers by Paul Toren in
Google Scholar
PubMed
Close

cancer, with androgen receptor (AR) pathway inhibitors used for castration-resistant prostate cancer (CRPC). Through the development and subsequent treatments for PCa, endocrine and paracrine systems regulate a prostate tumor microenvironment (TME), which

Free access
Helena Andrea Sterle Neuroimmunomodulation and Molecular Oncology Laboratory, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), and the National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina

Search for other papers by Helena Andrea Sterle in
Google Scholar
PubMed
Close
,
Ximena Hildebrandt Neuroimmunomodulation and Molecular Oncology Laboratory, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), and the National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina

Search for other papers by Ximena Hildebrandt in
Google Scholar
PubMed
Close
,
Matías Valenzuela Álvarez Remodeling Processes and Cellular Niches Laboratory, Institute of Translational Medicine and Biomedical Engineering (IMTIB), National Scientific and Technical Research Council (CONICET), Italian Hospital of Buenos Aires and the University Institute of the Italian Hospital (IUHI), Buenos Aires, Argentina

Search for other papers by Matías Valenzuela Álvarez in
Google Scholar
PubMed
Close
,
María Alejandra Paulazo Neuroimmunomodulation and Molecular Oncology Laboratory, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), and the National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina

Search for other papers by María Alejandra Paulazo in
Google Scholar
PubMed
Close
,
Luciana Mariel Gutierrez Remodeling Processes and Cellular Niches Laboratory, Institute of Translational Medicine and Biomedical Engineering (IMTIB), National Scientific and Technical Research Council (CONICET), Italian Hospital of Buenos Aires and the University Institute of the Italian Hospital (IUHI), Buenos Aires, Argentina

Search for other papers by Luciana Mariel Gutierrez in
Google Scholar
PubMed
Close
,
Alicia Juana Klecha Neuroimmunomodulation and Molecular Oncology Laboratory, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), and the National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina

Search for other papers by Alicia Juana Klecha in
Google Scholar
PubMed
Close
,
Florencia Cayrol Neuroimmunomodulation and Molecular Oncology Laboratory, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), and the National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina

Search for other papers by Florencia Cayrol in
Google Scholar
PubMed
Close
,
María Celeste Díaz Flaqué Neuroimmunomodulation and Molecular Oncology Laboratory, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), and the National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina

Search for other papers by María Celeste Díaz Flaqué in
Google Scholar
PubMed
Close
,
Cinthia Rosemblit Neuroimmunomodulation and Molecular Oncology Laboratory, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), and the National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina

Search for other papers by Cinthia Rosemblit in
Google Scholar
PubMed
Close
,
María Laura Barreiro Arcos Neuroimmunomodulation and Molecular Oncology Laboratory, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), and the National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina

Search for other papers by María Laura Barreiro Arcos in
Google Scholar
PubMed
Close
,
Lucas Colombo Immunobiology Department, Investigation Area, Institute of Oncology Angel H. Roffo, University of Buenos Aires (UBA), National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina

Search for other papers by Lucas Colombo in
Google Scholar
PubMed
Close
,
Marcela Fabiana Bolontrade Remodeling Processes and Cellular Niches Laboratory, Institute of Translational Medicine and Biomedical Engineering (IMTIB), National Scientific and Technical Research Council (CONICET), Italian Hospital of Buenos Aires and the University Institute of the Italian Hospital (IUHI), Buenos Aires, Argentina

Search for other papers by Marcela Fabiana Bolontrade in
Google Scholar
PubMed
Close
,
Vanina Araceli Medina Laboratory of Tumor Biology and Inflammation, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), and the National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina

Search for other papers by Vanina Araceli Medina in
Google Scholar
PubMed
Close
, and
Graciela Alicia Cremaschi Neuroimmunomodulation and Molecular Oncology Laboratory, Institute for Biomedical Research (BIOMED), School of Medical Sciences, Pontifical Catholic University of Argentina (UCA), and the National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina

Search for other papers by Graciela Alicia Cremaschi in
Google Scholar
PubMed
Close

. 2016 , Vikas et al. 2018 ). In addition to lymphocytes, the tumor microenvironment (TME) is formed by many other cell populations, such as other immunocompetent cells, vascular endothelial cells, mesenchymal stem cells (MSC) and cancer

Restricted access
Kensey Bergdorf Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

Search for other papers by Kensey Bergdorf in
Google Scholar
PubMed
Close
,
Donna C Ferguson Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

Search for other papers by Donna C Ferguson in
Google Scholar
PubMed
Close
,
Mitra Mehrad Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

Search for other papers by Mitra Mehrad in
Google Scholar
PubMed
Close
,
Kim Ely Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

Search for other papers by Kim Ely in
Google Scholar
PubMed
Close
,
Thomas Stricker Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

Search for other papers by Thomas Stricker in
Google Scholar
PubMed
Close
, and
Vivian L Weiss Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA

Search for other papers by Vivian L Weiss in
Google Scholar
PubMed
Close

, morphologic assessment of the primary tumor fails to predict the likelihood of metastatic or recurrent disease. We predict that the thyroid tumor immune microenvironment may play an important role in tumor behavior and may provide clues for improved targeted

Free access
Dominique D Liddy Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA

Search for other papers by Dominique D Liddy in
Google Scholar
PubMed
Close
,
Zhongyue Zhang University of Florida Health Cancer Center, Gainesville, Florida, USA

Search for other papers by Zhongyue Zhang in
Google Scholar
PubMed
Close
,
Kalyanee Shirlekar University of Florida Health Cancer Center, Gainesville, Florida, USA

Search for other papers by Kalyanee Shirlekar in
Google Scholar
PubMed
Close
,
Zhongping He University of Florida Health Cancer Center, Gainesville, Florida, USA
Department of Biostatistics, University of Florida College of Medicine, Gainesville, Florida, USA

Search for other papers by Zhongping He in
Google Scholar
PubMed
Close
,
Kelly M Herremans Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA

Search for other papers by Kelly M Herremans in
Google Scholar
PubMed
Close
,
Song Han Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA

Search for other papers by Song Han in
Google Scholar
PubMed
Close
,
Jason O Brant University of Florida Health Cancer Center, Gainesville, Florida, USA
Department of Biostatistics, University of Florida College of Medicine, Gainesville, Florida, USA

Search for other papers by Jason O Brant in
Google Scholar
PubMed
Close
,
Francis D Moore Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA

Search for other papers by Francis D Moore in
Google Scholar
PubMed
Close
,
Steven J Hughes Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA

Search for other papers by Steven J Hughes in
Google Scholar
PubMed
Close
, and
Aditya S Shirali Department of Surgery, University of Florida College of Medicine, Gainesville, Florida, USA

Search for other papers by Aditya S Shirali in
Google Scholar
PubMed
Close

, breast, and bone ( Grizzle et al. 2007 , Verschoor et al. 2013 , Ruhland et al. 2016 ). The contribution of specific immune cell types in the tumor microenvironment of papillary thyroid carcinoma, and the impact of age on the function of these

Restricted access
Yang Zhao Department of Endocrinology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China

Search for other papers by Yang Zhao in
Google Scholar
PubMed
Close
,
Cangang Zhang Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi’an Jiaotong University, Xi’an, Shaanxi, China

Search for other papers by Cangang Zhang in
Google Scholar
PubMed
Close
,
Yanan Zhu Department of Pathogenic Microbiology and Immunology, School of Basic Medical Sciences, Xi’an Jiaotong University, Xi’an, Shaanxi, China

Search for other papers by Yanan Zhu in
Google Scholar
PubMed
Close
,
Xi Ding Department of Endocrinology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China

Search for other papers by Xi Ding in
Google Scholar
PubMed
Close
,
Yikun Zhou Department of Endocrinology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China

Search for other papers by Yikun Zhou in
Google Scholar
PubMed
Close
,
Hongjun Lv Department of Endocrinology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China

Search for other papers by Hongjun Lv in
Google Scholar
PubMed
Close
,
Yuxuan Lin Department of Endocrinology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China

Search for other papers by Yuxuan Lin in
Google Scholar
PubMed
Close
,
Yuan Wu Department of Endocrinology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China

Search for other papers by Yuan Wu in
Google Scholar
PubMed
Close
,
Bingyin Shi Department of Endocrinology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China

Search for other papers by Bingyin Shi in
Google Scholar
PubMed
Close
, and
Jiao Fu Department of Endocrinology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China

Search for other papers by Jiao Fu in
Google Scholar
PubMed
Close

System ( van Velsen et al. 2019 ). However, many prognostic variables in this system are obtained during the follow-up period; thus, additional factors for earlier prediction of disease recurrence are required. The tumor immune microenvironment (TIM

Restricted access
Mijin Kim Department of Internal Medicine, Pusan National University School of Medicine, Yangsan, Korea
Biomedical Research Institute, Pusan National University Hospital, Busan, Korea

Search for other papers by Mijin Kim in
Google Scholar
PubMed
Close
,
Chae Hwa Kwon Biomedical Research Institute, Pusan National University Hospital, Busan, Korea

Search for other papers by Chae Hwa Kwon in
Google Scholar
PubMed
Close
, and
Bo Hyun Kim Department of Internal Medicine, Pusan National University School of Medicine, Yangsan, Korea
Biomedical Research Institute, Pusan National University Hospital, Busan, Korea

Search for other papers by Bo Hyun Kim in
Google Scholar
PubMed
Close

activation or inhibition is shown as positive or negative z -scores. Cell state and ecotype identification To identify features of the tumor microenvironment (TME), EcoTyper was used following the relevant web-based tutorial ( Luca et al. 2021

Restricted access
Maria Domenica Castellone Istituto di Endocrinologia ed Oncologia Sperimentale del CNR ‘G. Salvatore’, Naples, Italy

Search for other papers by Maria Domenica Castellone in
Google Scholar
PubMed
Close
and
Rosa Marina Melillo Istituto di Endocrinologia ed Oncologia Sperimentale del CNR ‘G. Salvatore’, Naples, Italy
Dipartimento di Medicina Molecolare e Biotecnologie Mediche, University of Naples ‘Federico II’, Naples, Italy

Search for other papers by Rosa Marina Melillo in
Google Scholar
PubMed
Close

pathways are indicated in blue boxes. Here, we will discuss how oncogenic RET signaling, in particular that associated with MEN2 syndromes, modulates gene expression and shapes the stromal and the immunologic components of tumor microenvironment

Free access
J T W Kwon Department of Oncology, University of Oxford, Oxford, UK

Search for other papers by J T W Kwon in
Google Scholar
PubMed
Close
,
R J Bryant Department of Oncology, University of Oxford, Oxford, UK
Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK

Search for other papers by R J Bryant in
Google Scholar
PubMed
Close
, and
E E Parkes Department of Oncology, University of Oxford, Oxford, UK

Search for other papers by E E Parkes in
Google Scholar
PubMed
Close

prostate cancer . Cancer Immunology, Immunotherapy 68 1621 – 1633 . ( https://doi.org/10.1007/s00262-019-02393-x ) Jiao S Subudhi SK Aparicio A Ge Z Guan B Miura Y Sharma P 2019 Differences in tumor microenvironment dictate T helper

Open access