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important target for cancer therapy. Fibroblasts within the tumour stroma are critically involved in promoting tumour growth and angiogenesis through secretion of soluble factors, synthesis of extracellular matrix and direct cell–cell interaction. Tumour-associated
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fibroblasts undergo activation in tumours, often then termed as tumour-associated fibroblasts (TAFs) ( Cirri & Chiarugi 2012 , Shiga et al. 2015 ). TAFs are an important source of cytokines and growth factors which contribute to their pro-tumoural effects
Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
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profile the transcriptome of 27,251 cells isolated from 4 PA tissues. Our work revealed the cellular heterogeneity, transcriptional states, and immune cell diversity inside PA tissues, underlying the role of tumour-associated fibroblasts (TAFs) and immune
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Department of Internal Medicine II, Medizinische Klinik und Poliklinik IV, Department of Biology II, Leibniz Institute for Environmental Medicine, Department of Nuclear Medicine, University Medical Center Hamburg‐Eppendorf, University Hospital of Munich, Munich, Germany
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Department of Internal Medicine II, Medizinische Klinik und Poliklinik IV, Department of Biology II, Leibniz Institute for Environmental Medicine, Department of Nuclear Medicine, University Medical Center Hamburg‐Eppendorf, University Hospital of Munich, Munich, Germany
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Introduction Tumours are composed of malignant tumour cells and the ‘benign’ stromal compartment that contains many distinct cell types, including endothelial cells, smooth muscle cells, cells of the immune system and pericytes/cancer-associated
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Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK
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prognosis by virtue of the hypermutated tumour phenotype possessing a greater neoantigen load and in turn, being associated with increased immune infiltration ( Graham et al. 2020 ). Approval was predicated on the pooled analysis of patients enrolled
Hormones and Cancer Group, Northern Clinical School, South Western Sydney Clinical School, Department of Surgery, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
Hormones and Cancer Group, Northern Clinical School, South Western Sydney Clinical School, Department of Surgery, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
Hormones and Cancer Group, Northern Clinical School, South Western Sydney Clinical School, Department of Surgery, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
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Hormones and Cancer Group, Northern Clinical School, South Western Sydney Clinical School, Department of Surgery, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
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Hormones and Cancer Group, Northern Clinical School, South Western Sydney Clinical School, Department of Surgery, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
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Hormones and Cancer Group, Northern Clinical School, South Western Sydney Clinical School, Department of Surgery, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
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Hormones and Cancer Group, Northern Clinical School, South Western Sydney Clinical School, Department of Surgery, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
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Hormones and Cancer Group, Northern Clinical School, South Western Sydney Clinical School, Department of Surgery, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
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Hormones and Cancer Group, Northern Clinical School, South Western Sydney Clinical School, Department of Surgery, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
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Hormones and Cancer Group, Northern Clinical School, South Western Sydney Clinical School, Department of Surgery, Endocrine and Oncology Surgery, Kolling Institute of Medical Research, Royal North Shore Hospital, Sydney, New South Wales, Australia
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fibroblasts, known as cancer-associated fibroblasts (CAFs), is important in tumour growth and progression ( Mueller & Fusenig 2004 ). These can be distinguished functionally from ‘normal’ fibroblasts in tissue distal from the tumour site. CAFs are believed to
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from our study concurs with a previous study by Xie et al. (2001 a ) on breast cancer in that Cyr61 is raised in breast tumours and is associated with aggressiveness of the tumours, including higher levels in NPI-3, nodal status, high grade, TNM-3
Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK
Department of Surgery, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
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Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham, UK
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have demonstrated that PBF is overexpressed in pituitary, thyroid, breast and colorectal tumours, and that upregulation of the gene is significantly associated with poorer oncological outcome in a range of tumours ( McCabe et al . 2003 , Stratford
Cancer Genetics, Department of Surgery, Department of Biochemistry, Hormones and Cancer, Kolling Institute of Medical Research, University of Sydney, Level 9, Kolling Building, Royal North Shore Hospital, St Leonards, Sydney, New South Wales, Australia
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carcinogenesis ( Paland et al . 2009 ), cancer-associated fibroblasts (CAFs) create an environment that is conducive to tumour initiation and progression ( Olumi et al . 1999 , Hayward et al . 2001 , Orimo et al . 2005 , Soon et al . 2013 ). The
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tumourigenesis Considerable literature details the potential pathogenic changes in sporadic pituitary tumours that include hormones, growth factors, receptors, associated signal transduction pathways and cell-cycle regulators. A detailed consideration