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James F Powers Department of Pathology and Laboratory Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA

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Brent Cochran Department of Developmental, Molecular and Chemical Biology

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James D Baleja Department of Developmental, Molecular and Chemical Biology

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Hadley D Sikes Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

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Andrew D Pattison Department of Clinical Pathology, University of Melbourne, Melbourne, Victoria, Australia

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Xue Zhang Department of Developmental, Molecular and Chemical Biology

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Inna Lomakin Department of Pathology and Laboratory Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA

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Annette Shepard-Barry Department of Pathology and Laboratory Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA

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Karel Pacak Section on Medical Neuroendocrinology, Eunice Kennedy Shriver Division National Institute of Child Health and Human Development, Bethesda, Maryland, USA

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Sun Jin Moon Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

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Troy F Langford Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

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Kassi Taylor Stein Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

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Richard W Tothill Department of Clinical Pathology, University of Melbourne, Melbourne, Victoria, Australia
Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia

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Yingbin Ouyang Cyagen US Inc, Santa Clara, California, USA

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Arthur S Tischler Department of Pathology and Laboratory Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA

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develop PCCs, we hypothesized that rats would a priori be superior to mice as a potential Sdhb tumor model. This communication describes the successful development of a new rat-derived xenograft and cell culture model that closely mirrors the

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-19-0474
Volume/Issue:
Volume 27: Issue 6
Open access
Colette Meyer
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Andrew H Sims
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Kevin Morgan Breakthrough Breast Cancer Research Unit and Division of Pathology, Medical Research Council Human Reproductive Sciences Unit, Centre for Integrative Physiology, Mammal Research Institute, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XU, UK

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Beth Harrison
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Morwenna Muir
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Jianing Bai
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Dana Faratian
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Robert P Millar Breakthrough Breast Cancer Research Unit and Division of Pathology, Medical Research Council Human Reproductive Sciences Unit, Centre for Integrative Physiology, Mammal Research Institute, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XU, UK
Breakthrough Breast Cancer Research Unit and Division of Pathology, Medical Research Council Human Reproductive Sciences Unit, Centre for Integrative Physiology, Mammal Research Institute, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XU, UK

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Simon P Langdon
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(SCL60) cells in vitro and in tumor xenografts to identify markers likely to reflect the anti-proliferative mechanism. This model is a HEK293 cell line transfected with a high level of the GNRHR ( Morgan et al . 2008 ). In most published studies of

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-12-0192
Volume/Issue:
Volume 20: Issue 1
Open access
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James F Powers Department of Pathology and Laboratory Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA

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Brent Cochran Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts, USA

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James D Baleja Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts, USA

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Hadley D Sikes Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

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Xue Zhang Department of Developmental, Molecular and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts, USA

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Inna Lomakin Department of Pathology and Laboratory Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA

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Troy Langford Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

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Kassi Taylor Stein Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

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Arthur S Tischler Department of Pathology and Laboratory Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA

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(Champions Oncology, Hackensack, NJ, USA) in nude mice from a tumor deposit in the patient’s abdomen. With authorization from the deceased patient’s family, we received cryopreserved passage 3 xenograft tissue and expanded through passage 6 in nude and/or NSG

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-18-0115
Volume/Issue:
Volume 25: Issue 11
Free access
Arthur S Tischler Department of Pathology and Laboratory Medicine, Tufts Medical Center and Tufts University School of Medicine, Boston, Massachusetts, USA

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Judith Favier Université Paris cité, Inserm UMR970 PARCC, Equipe Labellisée par la Ligue contre le cancer, Paris, France

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Experimental models including xenografts and cell lines derived from multiple human tumors provide a critical foundation for preclinical cancer research. These are complemented by mouse models engineered to develop tumors that faithfully

Article Type:
Review Article
Collections:
Advances and Future Directions in Pheochromocytoma and Paraganglioma
DOI:
https://doi.org/10.1530/ERC-22-0405
Volume/Issue:
Volume 30: Issue 5
Free access
Jean-Pierre Bayley Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands

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Peter Devilee Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands
Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands

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several cell lines derived from human sources, and then provide a brief overview of xenograft models. Cell models are listed briefly in Table 1 and are more extensively summarized in Supplementary Table 1 (see section on supplementary materials given

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-19-0434
Volume/Issue:
Volume 27: Issue 12
Free access
Lisa K Philp Australian Prostate Cancer Research Centre - Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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Anja Rockstroh Australian Prostate Cancer Research Centre - Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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Martin C Sadowski Australian Prostate Cancer Research Centre - Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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Atefeh Taherian Fard Australian Prostate Cancer Research Centre - Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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Melanie Lehman Australian Prostate Cancer Research Centre - Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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Gregor Tevz Australian Prostate Cancer Research Centre - Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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Michelle S Libério Australian Prostate Cancer Research Centre - Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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Charles L Bidgood Australian Prostate Cancer Research Centre - Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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Jennifer H Gunter Australian Prostate Cancer Research Centre - Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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Stephen McPherson Australian Prostate Cancer Research Centre - Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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Nenad Bartonicek Garvan Institute of Medical Research, Sydney, New South Wales, Australia

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John D Wade Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia
School of Chemistry, University of Melbourne, Melbourne, Victoria, Australia

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Laszlo Otvos OLPE, LLC, Audubon, Pennsylvania, USA
Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary

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Colleen C Nelson Australian Prostate Cancer Research Centre - Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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.05 indicates validated knockdown in +Dox vs no Dox). Significant: * P ≤ 0.05. (D) LEPR mRNA expression (by microarray) in an LNCaP prostate cancer progression xenograft model in mice. Xenografts were harvested from intact mice or mice that underwent

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-20-0405
Volume/Issue:
Volume 28: Issue 5
Restricted access
John W Cassidy Breast Cancer Functional Genomics, CRUK Cambridge Research Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK

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Ankita S Batra Breast Cancer Functional Genomics, CRUK Cambridge Research Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK

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Wendy Greenwood Breast Cancer Functional Genomics, CRUK Cambridge Research Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, UK

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Alejandra Bruna Department of Oncology, University of Cambridge, Cambridge, UK

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-derived tumour xenografts (PDTXs) ( Whittle et al. 2015 ), which retain the complex heterogeneity of their originating tumour samples ( DeRose et al. 2011 , Cassidy et al. 2015 , Eirew et al. 2015 ). PDTX models of BC resemble primary tumours across the

Article Type:
Review Article
DOI:
https://doi.org/10.1530/ERC-16-0251
Volume/Issue:
Volume 23: Issue 12
Open access
Lisa K Philp Australian Prostate Cancer Research Centre – Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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Anja Rockstroh Australian Prostate Cancer Research Centre – Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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Melanie Lehman Australian Prostate Cancer Research Centre – Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia
Vancouver Prostate Centre, Department of Urologic Sciences, University of British Columbia, Vancouver, Canada

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Martin C Sadowski Australian Prostate Cancer Research Centre – Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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Nenad Bartonicek Garvan Institute of Medical Research, Sydney, New South Wales, Australia

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John D Wade Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia
School of Chemistry, University of Melbourne, Melbourne, Victoria, Australia

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Laszlo Otvos Jr OLPE, LLC, Audubon, Pennsylvania, USA
Institute of Medical Microbiology, Semmelweis University, Budapest, Hungary

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Colleen C Nelson Australian Prostate Cancer Research Centre – Queensland, Institute of Health and Biomedical Innovation, School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Princess Alexandra Hospital, Translational Research Institute, Brisbane, Queensland, Australia

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://www.betastasis.com ; Taylor dataset). Cell culture for xenografts LNCaP cells (CVCL_0395, ATCC) were grown as described in ( Tousignant et al. 2019 ) with routine mycoplasma testing and authentication by short tandem repeat DNA profiling (December 2017 and March

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-20-0297
Volume/Issue:
Volume 27: Issue 12
Restricted access
Anton Neschadim
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Laura B Pritzker Armour Therapeutics Inc., Rna Diagnostics Inc., Departments of Laboratory Medicine and Pathobiology, Surgery, Pathology and Laboratory Medicine, Departments of Medicine, Laboratory Medicine and Pathobiology, Centre for Innovation, Division of Advanced Diagnostics – Infection and Immunity, Department of Biomedical Sciences, Departments of Surgery and Medical Imaging, Division of Urology, Prostate Centre, Ontario Cancer Institute, 124 Orchard View Boulevard, Toronto, Ontario, Canada

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Kenneth P H Pritzker Armour Therapeutics Inc., Rna Diagnostics Inc., Departments of Laboratory Medicine and Pathobiology, Surgery, Pathology and Laboratory Medicine, Departments of Medicine, Laboratory Medicine and Pathobiology, Centre for Innovation, Division of Advanced Diagnostics – Infection and Immunity, Department of Biomedical Sciences, Departments of Surgery and Medical Imaging, Division of Urology, Prostate Centre, Ontario Cancer Institute, 124 Orchard View Boulevard, Toronto, Ontario, Canada
Armour Therapeutics Inc., Rna Diagnostics Inc., Departments of Laboratory Medicine and Pathobiology, Surgery, Pathology and Laboratory Medicine, Departments of Medicine, Laboratory Medicine and Pathobiology, Centre for Innovation, Division of Advanced Diagnostics – Infection and Immunity, Department of Biomedical Sciences, Departments of Surgery and Medical Imaging, Division of Urology, Prostate Centre, Ontario Cancer Institute, 124 Orchard View Boulevard, Toronto, Ontario, Canada
Armour Therapeutics Inc., Rna Diagnostics Inc., Departments of Laboratory Medicine and Pathobiology, Surgery, Pathology and Laboratory Medicine, Departments of Medicine, Laboratory Medicine and Pathobiology, Centre for Innovation, Division of Advanced Diagnostics – Infection and Immunity, Department of Biomedical Sciences, Departments of Surgery and Medical Imaging, Division of Urology, Prostate Centre, Ontario Cancer Institute, 124 Orchard View Boulevard, Toronto, Ontario, Canada
Armour Therapeutics Inc., Rna Diagnostics Inc., Departments of Laboratory Medicine and Pathobiology, Surgery, Pathology and Laboratory Medicine, Departments of Medicine, Laboratory Medicine and Pathobiology, Centre for Innovation, Division of Advanced Diagnostics – Infection and Immunity, Department of Biomedical Sciences, Departments of Surgery and Medical Imaging, Division of Urology, Prostate Centre, Ontario Cancer Institute, 124 Orchard View Boulevard, Toronto, Ontario, Canada

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Donald R Branch Armour Therapeutics Inc., Rna Diagnostics Inc., Departments of Laboratory Medicine and Pathobiology, Surgery, Pathology and Laboratory Medicine, Departments of Medicine, Laboratory Medicine and Pathobiology, Centre for Innovation, Division of Advanced Diagnostics – Infection and Immunity, Department of Biomedical Sciences, Departments of Surgery and Medical Imaging, Division of Urology, Prostate Centre, Ontario Cancer Institute, 124 Orchard View Boulevard, Toronto, Ontario, Canada
Armour Therapeutics Inc., Rna Diagnostics Inc., Departments of Laboratory Medicine and Pathobiology, Surgery, Pathology and Laboratory Medicine, Departments of Medicine, Laboratory Medicine and Pathobiology, Centre for Innovation, Division of Advanced Diagnostics – Infection and Immunity, Department of Biomedical Sciences, Departments of Surgery and Medical Imaging, Division of Urology, Prostate Centre, Ontario Cancer Institute, 124 Orchard View Boulevard, Toronto, Ontario, Canada
Armour Therapeutics Inc., Rna Diagnostics Inc., Departments of Laboratory Medicine and Pathobiology, Surgery, Pathology and Laboratory Medicine, Departments of Medicine, Laboratory Medicine and Pathobiology, Centre for Innovation, Division of Advanced Diagnostics – Infection and Immunity, Department of Biomedical Sciences, Departments of Surgery and Medical Imaging, Division of Urology, Prostate Centre, Ontario Cancer Institute, 124 Orchard View Boulevard, Toronto, Ontario, Canada
Armour Therapeutics Inc., Rna Diagnostics Inc., Departments of Laboratory Medicine and Pathobiology, Surgery, Pathology and Laboratory Medicine, Departments of Medicine, Laboratory Medicine and Pathobiology, Centre for Innovation, Division of Advanced Diagnostics – Infection and Immunity, Department of Biomedical Sciences, Departments of Surgery and Medical Imaging, Division of Urology, Prostate Centre, Ontario Cancer Institute, 124 Orchard View Boulevard, Toronto, Ontario, Canada

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Alastair J S Summerlee Armour Therapeutics Inc., Rna Diagnostics Inc., Departments of Laboratory Medicine and Pathobiology, Surgery, Pathology and Laboratory Medicine, Departments of Medicine, Laboratory Medicine and Pathobiology, Centre for Innovation, Division of Advanced Diagnostics – Infection and Immunity, Department of Biomedical Sciences, Departments of Surgery and Medical Imaging, Division of Urology, Prostate Centre, Ontario Cancer Institute, 124 Orchard View Boulevard, Toronto, Ontario, Canada

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John Trachtenberg Armour Therapeutics Inc., Rna Diagnostics Inc., Departments of Laboratory Medicine and Pathobiology, Surgery, Pathology and Laboratory Medicine, Departments of Medicine, Laboratory Medicine and Pathobiology, Centre for Innovation, Division of Advanced Diagnostics – Infection and Immunity, Department of Biomedical Sciences, Departments of Surgery and Medical Imaging, Division of Urology, Prostate Centre, Ontario Cancer Institute, 124 Orchard View Boulevard, Toronto, Ontario, Canada
Armour Therapeutics Inc., Rna Diagnostics Inc., Departments of Laboratory Medicine and Pathobiology, Surgery, Pathology and Laboratory Medicine, Departments of Medicine, Laboratory Medicine and Pathobiology, Centre for Innovation, Division of Advanced Diagnostics – Infection and Immunity, Department of Biomedical Sciences, Departments of Surgery and Medical Imaging, Division of Urology, Prostate Centre, Ontario Cancer Institute, 124 Orchard View Boulevard, Toronto, Ontario, Canada
Armour Therapeutics Inc., Rna Diagnostics Inc., Departments of Laboratory Medicine and Pathobiology, Surgery, Pathology and Laboratory Medicine, Departments of Medicine, Laboratory Medicine and Pathobiology, Centre for Innovation, Division of Advanced Diagnostics – Infection and Immunity, Department of Biomedical Sciences, Departments of Surgery and Medical Imaging, Division of Urology, Prostate Centre, Ontario Cancer Institute, 124 Orchard View Boulevard, Toronto, Ontario, Canada
Armour Therapeutics Inc., Rna Diagnostics Inc., Departments of Laboratory Medicine and Pathobiology, Surgery, Pathology and Laboratory Medicine, Departments of Medicine, Laboratory Medicine and Pathobiology, Centre for Innovation, Division of Advanced Diagnostics – Infection and Immunity, Department of Biomedical Sciences, Departments of Surgery and Medical Imaging, Division of Urology, Prostate Centre, Ontario Cancer Institute, 124 Orchard View Boulevard, Toronto, Ontario, Canada

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Joshua D Silvertown
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) renders it a receptor antagonist, thereby neutralizing endogenous H2 relaxin signaling ( Silvertown et al . 2007 , Hossain et al . 2010 ). We showed that recombinant human H2 relaxin receptor antagonist expressed from prostate cancer xenografts results

Article Type:
Research Article
DOI:
https://doi.org/10.1530/ERC-14-0088
Volume/Issue:
Volume 21: Issue 3
Free access
Debbie Clements
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Sarah L Asprey
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Thomas A McCulloch Division of Therapeutics and Molecular Medicine, Department of Histopathology, Academic Unit of Cancer Studies, D Floor, South Block, University Hospital, University of Nottingham, Nottingham NG7 2UH, UK

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Theresa A Morris Division of Therapeutics and Molecular Medicine, Department of Histopathology, Academic Unit of Cancer Studies, D Floor, South Block, University Hospital, University of Nottingham, Nottingham NG7 2UH, UK

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Susan A Watson Division of Therapeutics and Molecular Medicine, Department of Histopathology, Academic Unit of Cancer Studies, D Floor, South Block, University Hospital, University of Nottingham, Nottingham NG7 2UH, UK

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Simon R Johnson
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angiomyolipoma cell line developed by Arbiser et al . (2001) , we have generated an oestrogen responsive mouse xenograft model to examine how oestrogen leads to increased growth in angiomyolipoma and LAM. Methods Angiomyolipoma cells, tissue and ethical

Article Type:
Research Article
DOI:
https://doi.org/10.1677/ERC-08-0123
Volume/Issue:
Volume 16: Issue 1
Free access