Detection of the differentially expressed gene IGF-binding protein-related protein-1 and analysis of its relationship to fasting glucose in Chinese colorectal cancer patients.

in Endocrine-Related Cancer
Authors:
L Shao Department of Pathology, School of Medicine, Zhejiang University, Hangzhou 310031, People's Republic of China. lmd@sun.zju.edu.cn

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Q Huang Department of Pathology, School of Medicine, Zhejiang University, Hangzhou 310031, People's Republic of China. lmd@sun.zju.edu.cn

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M Luo Department of Pathology, School of Medicine, Zhejiang University, Hangzhou 310031, People's Republic of China. lmd@sun.zju.edu.cn

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M Lai Department of Pathology, School of Medicine, Zhejiang University, Hangzhou 310031, People's Republic of China. lmd@sun.zju.edu.cn

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DOI:
https://doi.org/10.1677/erc.0.0110141
Volume/Issue:
Volume 11: Issue 1
Article Type:
Abstract
Page Range:
141–148
Online Publication Date:
Mar 2004
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IGF-binding protein-related protein-1 (IGFBP-rP1) is a member of the IGF axis. In our previous work, we separated cDNA fragments of IGFBP-rP1 from colonic adenocarcinoma and normal mucosa cDNA subtraction libraries. In this study, we compared the expression of IGFBP-rP1 by semi-quantitative RT-PCR and immunohistochemistry among colorectal cancer, adenoma, normal tissue adjacent to cancer site, and normal tissue. Associations between IGFBP-rP1 and plasma glucose were further explored. We found that the mRNA level of IGFBP-rP1 was highest in cancer, moderate in adenoma and tissue adjacent to the cancer site and lowest in normal tissue (P<0.05). A significant difference was found in the immunoreactivity of IGFBP-rP1 between paired normal and cancer tissue (P<0.05). Tumor samples with upregulated expression of IGFBP-rP1 in invading tumor cells showed an increased frequency of metastasis to the lymph node, an increased depth of infiltration and stronger staining of IGFBP-rP1 compared with other samples (P<0.05). The fasting glucose level was significantly correlated with the staining of IGFBP-rP1 in cancer tissue (Spearman's rho=0.4, P<0.000). Thus, we concluded overexpression of IGFBP-rP1 might play an important role in the initiation and promotion of colorectal cancer. IGFBP-rP1 expression may also be associated with fasting glucose level and the presence of diabetes mellitus.

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Print ISSN:
1351-0088
Online ISSN:
1479-6821
Page(s):
8
Print Publication Date:
01 Jan 2004
Online Publication Date:
Mar 2004