Spontaneous enterochromaffin-like cell carcinomas in cotton rats (Sigmodon hispidus) are prevented by a somatostatin analogue.

in Endocrine-Related Cancer
Authors:
R Fossmark Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, MTFS, Olav Kyrres gt 3, N-7489 Trondheim, Norway.

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T C Martinsen Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, MTFS, Olav Kyrres gt 3, N-7489 Trondheim, Norway.

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S H Torp Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, MTFS, Olav Kyrres gt 3, N-7489 Trondheim, Norway.

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S Kawase Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, MTFS, Olav Kyrres gt 3, N-7489 Trondheim, Norway.

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A K Sandvik Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, MTFS, Olav Kyrres gt 3, N-7489 Trondheim, Norway.

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H L Waldum Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, MTFS, Olav Kyrres gt 3, N-7489 Trondheim, Norway.

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DOI:
https://doi.org/10.1677/erc.0.0110149
Volume/Issue:
Volume 11: Issue 1
Article Type:
Abstract
Page Range:
149–160
Online Publication Date:
Mar 2004
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Among inbred female cotton rats (Sigmodon hispidus) 25-50% of the animals develop spontaneous gastric carcinomas; the corresponding figure for male cotton rats is approximately 1%. Animals with carcinomas have hypergastrinaemia and gastric hypo-anacidity and the tumours are derived from enterochromaffin-like (ECL) cells. The mechanism behind the hypo-anacidity is unknown. Carcinomas are found in all female cotton rats with hypergastrinaemia lasting more than 4 months and this represents an excellent animal model for studying gastric carcinogenesis. In this study, the somatostatin analogue octreotide was given to female cotton rats to prevent carcinoma development caused by hypergastrinaemia. Twelve female cotton rats were given monthly injections of long-acting octreotide (5 mg i.m.) for 6 months. A control group of 20 animals was not given injections. Of the 20 control animals, 13 developed hypergastrinaemia and histologically invasive carcinomas or dysplasia. Of the 12 animals in the octreotide group, five developed hypergastrinaemia. None of these five animals developed histological cancer (P<0.05), whereas three had dysplasia. However, octreotide did not affect plasma gastrin concentration or antral gastrin mRNA abundance significantly. Dysplasia of the oxyntic mucosa in hypergastrinaemic animals was accompanied by a marked increase in chromogranin A-immunoreactive cells and cells positive for Sevier-Munger staining. The malignant tissue also contained groups of cells with Sevier-Munger staining. In conclusion, octreotide prevented ECL cell carcinomas in hypergastrinaemic cotton rats without lowering the gastrin concentration.

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Print ISSN:
1351-0088
Online ISSN:
1479-6821
Page(s):
12
Print Publication Date:
01 Jan 2004
Online Publication Date:
Mar 2004