A lex naturalis delineates components of a human-specific, adrenal androgen-dependent, p53-mediated ‘kill switch’ tumor suppression mechanism

in Endocrine-Related Cancer
Author:
Jonathan Wesley Nyce ACGT Biotechnology, Collegeville, Pennsylvania, USA

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Correspondence should be addressed to J W Nyce: nyce.jonathan@acgt.us
DOI:
https://doi.org/10.1530/ERC-19-0382a
Volume/Issue:
Volume 27: Issue 9
Article Type:
Correction
Page Range:
X7
Online Publication Date:
Sep 2020
Copyright:
© 2020 Society for Endocrinology 2020
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The author and journal apologise for an omission in the above paper, which appeared in volume 27 part 2, pages R51–R65. The author wishes to provide a full definition of the variables given in the legend of Fig. 3 on page R55.

The amended legend to Fig. 3 is given in full below:

Figure 3
Figure 3

A normalized lex naturalis equation, representing a snapshot of a species with the dependent variables adult body size (S), lifespan (Li), species-specific mechanism of tumor suppression (T), and carcinogen exposure (E) in equilibrium to maintain lifetime cancer risk (R), at a value of about 4%. We have previously defined a singularity as the original transformed, tumor-competent cell, while it is still in its single cell state. T is the probability of successful extinction of singularities by a particular species-specific tumor suppression mechanism, and hence its value is represented as a reciprocal, 1/T. R is a measure of the probability of developing cancer at some time during the lifespan, and hence its value is also represented as a reciprocal, 1/R. These facts enable algebraic manipulation of the equation, e.g., Li = T/SER.

Citation: Endocrine-Related Cancer 27, 9; 10.1530/ERC-19-0382a

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Print ISSN:
1351-0088
Online ISSN:
1479-6821
Copyright:
© 2020 Society for Endocrinology 2020
Print Publication Date:
01 Sep 2020
Online Publication Date:
Sep 2020
  • Figure 3
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    Figure 3

    A normalized lex naturalis equation, representing a snapshot of a species with the dependent variables adult body size (S), lifespan (Li), species-specific mechanism of tumor suppression (T), and carcinogen exposure (E) in equilibrium to maintain lifetime cancer risk (R), at a value of about 4%. We have previously defined a singularity as the original transformed, tumor-competent cell, while it is still in its single cell state. T is the probability of successful extinction of singularities by a particular species-specific tumor suppression mechanism, and hence its value is represented as a reciprocal, 1/T. R is a measure of the probability of developing cancer at some time during the lifespan, and hence its value is also represented as a reciprocal, 1/R. These facts enable algebraic manipulation of the equation, e.g., Li = T/SER.

Figure 3

A normalized lex naturalis equation, representing a snapshot of a species with the dependent variables adult body size (S), lifespan (Li), species-specific mechanism of tumor suppression (T), and carcinogen exposure (E) in equilibrium to maintain lifetime cancer risk (R), at a value of about 4%. We have previously defined a singularity as the original transformed, tumor-competent cell, while it is still in its single cell state. T is the probability of successful extinction of singularities by a particular species-specific tumor suppression mechanism, and hence its value is represented as a reciprocal, 1/T. R is a measure of the probability of developing cancer at some time during the lifespan, and hence its value is also represented as a reciprocal, 1/R. These facts enable algebraic manipulation of the equation, e.g., Li = T/SER.