Microarrays in primary breast cancer--lessons from chemotherapy studies.

in Endocrine-Related Cancer
Authors:
P E L√∏nning Section of Oncology, Department of Medicine, Haukeland University Hospital, Bergen, Norway. plon@haukeland.no

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T S√∏rlie Section of Oncology, Department of Medicine, Haukeland University Hospital, Bergen, Norway. plon@haukeland.no

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C M Perou Section of Oncology, Department of Medicine, Haukeland University Hospital, Bergen, Norway. plon@haukeland.no

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P O Brown Section of Oncology, Department of Medicine, Haukeland University Hospital, Bergen, Norway. plon@haukeland.no

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D Botstein Section of Oncology, Department of Medicine, Haukeland University Hospital, Bergen, Norway. plon@haukeland.no

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A L B√∏rresen-Dale Section of Oncology, Department of Medicine, Haukeland University Hospital, Bergen, Norway. plon@haukeland.no

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Current development in molecular techniques has extended the opportunities to explore genetic alterations in malignant tissue. There is a need to improve prognostication and, in particular, to understand the mechanisms of treatment resistance in different tumours. Gene analyses by microarrays allow concomitant analyses of several genes in concert, providing new opportunities for tumour classification and understanding of key biological disturbances. This paper outlines our continuing studies exploring prognostic and, we hope, predictive factors in breast cancer therapy.

 

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